Comparison of the effects of various anticancer agents on intestinal anastomosis after intraperitoneal administration

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dc.contributor.authorArıkan, A. Yüksel
dc.contributor.authorŞenel, Ferda M.
dc.contributor.authorAkman, R. Yavuz
dc.contributor.authorCan, Cevat
dc.date.accessioned2020-04-30T22:41:28Z
dc.date.available2020-04-30T22:41:28Z
dc.date.issued1999
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000081910200010en_US
dc.descriptionPubMed: 10483749en_US
dc.description.abstractIn this study, the effects of intraperitoneal 5-fluorouracil (5-FU), cisplatinum (Cis), adriamycin (Adr), and methotrexate (MTX) administration on rat intestinal anastomosis were compared. Cis and MTX led to significant weight loss in the first 5 days compared with the control group. Within 14 days all rats except the MTX group nearly reached their preoperative weight. No remarkable weight loss or systemic toxicity was observed among the 5-FU and Adr groups. The anastomosis bursting pressure (ABP) at 1 week was significantly lower than that of the control group (P < 0.01 and P < 0.005, respectively). On day 14 the anastomosis bursting pressure in the Cis group was similar to that of the control group but was significantly lower in the MTX group (P < 0.002). Histopathologically, MTX avoided the development of a mucosal layer at the anastomosis site and led to ulcer formation in some of the rats, The ABPs at 7 and 14 days were similar to those in the control group. Neither of the agents had any significant mechanical or histopathologic adverse effects on anastomosis, According to the results of our study, MTX impaired the healing of the anastomosis, and we thus conclude that the intraperitoneal administration of this agent is not safe. On the other hand, Cis showed a detrimental effect on the anastomosis, particularly in the early phase, but this effect disappeared in the late phase. Cis thus should not be administered in the early postoperative phase. As a result, 5-FU and Adr were found to be the safest agents as they did not delay wound healing and did not reduce the anastomotic strength.en_US
dc.identifier.endpage746en_US
dc.identifier.issn0941-1291
dc.identifier.issue8en_US
dc.identifier.startpage741en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3193
dc.identifier.volume29en_US
dc.identifier.wosWOS:000081910200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofSurgery Today-The Japanese Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantineoplastic agenten_US
dc.subjectintestinal anastomosisen_US
dc.subjectwound healingen_US
dc.titleComparison of the effects of various anticancer agents on intestinal anastomosis after intraperitoneal administrationen_US
dc.typeArticleen_US

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