Altered serum levels of vascular endothelial growth factor and glial-derived neurotrophic factor but not fibroblast growth factor-2 in treatment-naive children with attention deficit/hyperactivity disorder

Basit Öğe Kaydı
dc.contributor.authorYurteri, Nihal
dc.contributor.authorŞahin, İbrahim Ethem
dc.contributor.authorTufan, Ali Evren
dc.date.accessioned2020-04-30T22:39:05Z
dc.date.available2020-04-30T22:39:05Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionTUFAN, ALI EVREN/0000-0001-5207-6240en_US
dc.descriptionWOS: 000473477000013en_US
dc.descriptionPubMed: 31170860en_US
dc.description.abstractBackground and aim: Recent evidence suggests that growth factors might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). The aim of this study was to determine whether serum levels of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), neurotrophin-3 (NT-3), nerve growth factor (NGF), fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) were altered in children with ADHD.Methods: Serum levels of BDNF, GDNF, NT-3, NGF, VEGF and FGF-2 were analyzed in 49 treatment- naive children with ADHD and age, gender matched 36 healthy controls using enzyme-linked immunosorbent assay. ADHD symptoms were scored by Du Paul ADHD Rating Scale and Strengths and Difficulties Questionnaire.Results: We found that serum VEGF levels were significantly lower (p<0.001) and GDNF levels were significantly higher in ADHD group compared to control group (p=0.003). However, we found no correlations between ADHD symptoms and serum VEGF or GDNF levels. Furthermore, we observed no significant alterations in serum BDNF, NT-3, NGF, FGF-2 levels in children with ADHD.Conclusion: To our knowledge, the present study is the first to examine serum VEGF and FGF-2 levels in children with ADHD. Our results indicate that VEGF and GDNF might be involved in the etiology of ADHD. Further studies are required to determine the role of growth factors in the etiology and consequently in the treatment of ADHD.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Duzce UniversityDuzce Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Project Coordination Unit of Duzce University.en_US
dc.identifier.doi10.1080/08039488.2019.1625437en_US
dc.identifier.endpage307en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue04.Mayen_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.1080/08039488.2019.1625437
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2596
dc.identifier.volume73en_US
dc.identifier.wosWOS:000473477000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNordic Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAttention deficit hyperactivity disorderen_US
dc.subjectbrain-derived neurotrophic factoren_US
dc.subjectglial-derived neurotrophic factoren_US
dc.subjectneurotrophin-3en_US
dc.subjectnerve growth factoren_US
dc.subjectvascular endothelial growth factoren_US
dc.subjectfibroblast growth factor-2en_US
dc.titleAltered serum levels of vascular endothelial growth factor and glial-derived neurotrophic factor but not fibroblast growth factor-2 in treatment-naive children with attention deficit/hyperactivity disorderen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
2596.pdf
Boyut:
666.78 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu