Clindamycin phosphate and bone morphogenetic protein-7 loaded combined nanoparticle-graft and nanoparticle-film formulations for alveolar bone regeneration-An in vitro and in vivo evaluation

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dc.authoridİlhan, Miray/0000-0003-1749-5129en_US
dc.authoridEkim, Okan/0000-0002-3322-4161en_US
dc.authoridKılıçarslan, Müge/0000-0003-3710-7445en_US
dc.authorscopusid57203248807en_US
dc.authorscopusid6602611180en_US
dc.authorscopusid30867562400en_US
dc.authorscopusid55841460300en_US
dc.authorscopusid27867617200en_US
dc.authorscopusid8502419700en_US
dc.authorwosidİlhan, Miray/GQZ-8312-2022en_US
dc.authorwosidEkim, Okan/AAH-7489-2020en_US
dc.authorwosidKılıçarslan, Müge/AAG-1353-2020en_US
dc.contributor.authorIlhan, Miray
dc.contributor.authorKilicarslan, Muge
dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorBagis, Nilsun
dc.contributor.authorEkim, Okan
dc.contributor.authorOrhan, Kaan
dc.date.accessioned2024-08-23T16:04:44Z
dc.date.available2024-08-23T16:04:44Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractCommonly utilized techniques for healing alveolar bone destruction such as the use of growth factors, suffering from short half-life, application difficulties, and the ability to achieve bioactivity only in the presence of high doses of growth factor. The sustained release of growth factors through a scaffold-based delivery system offers a promising and innovative tool in dentistry. Furthermore, it is suggested to guide the host response by using antimicrobials together with growth factors to prevent recovery and achieve ideal regeneration. Herein, the aim was to prepare and an in vitro -in vivo evaluation of bone morphogenetic protein 7 (BMP-7) and clindamycin phosphate (CDP) loaded polymeric nanoparticles, and their loading into the alginate-chitosan polyelectrolyte complex film or alloplastic graft to accelerate hard tissue regeneration. PLGA nanoparticles containing CDP and BMP-7, separately or together, were prepared using the double emulsion solvent evaporation technique. Through in vitro assays, it was revealed that spherical particles were homogeneously distributed in the combination formulations, and sustained release could be achieved for >12 weeks with all formulations. Also, results from the micro-CT and histopathological analyses indicated that CDP and BMP-7 loaded nanoparticle-film formulations were more effective in treatment than the nanoparticle loaded grafts.en_US
dc.description.sponsorshipAnkara University, Coordinator of Scientific Research Projects [17A0234001]en_US
dc.description.sponsorshipThis research was supported by Ankara University, Coordinator of Scientific Research Projects (Grant number: 17A0234001).en_US
dc.identifier.doi10.1016/j.ijpharm.2023.122826
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.pmid36918117en_US
dc.identifier.scopus2-s2.0-85151467240en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2023.122826
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14336
dc.identifier.volume636en_US
dc.identifier.wosWOS:000957727200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone morphogenetic proteinen_US
dc.subjectBone regenerationen_US
dc.subjectClindamycin phosphateen_US
dc.subjectGraften_US
dc.subjectNanoparticleen_US
dc.subjectPolyelectrolyte complex filmen_US
dc.subjectSequential Bmp-2/Bmp-7 Deliveryen_US
dc.subjectMesoporous Silica Nanoparticlesen_US
dc.subjectControlled-Releaseen_US
dc.subjectDrug-Deliveryen_US
dc.subjectTissue Regenerationen_US
dc.subjectStem-Cellsen_US
dc.subjectScaffoldsen_US
dc.subjectSystemen_US
dc.subjectMicroparticlesen_US
dc.subjectMicrospheresen_US
dc.titleClindamycin phosphate and bone morphogenetic protein-7 loaded combined nanoparticle-graft and nanoparticle-film formulations for alveolar bone regeneration-An in vitro and in vivo evaluationen_US
dc.typeArticleen_US

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