The Effects of Phenyramidol and Diclofenac Treatment on Fracture Healing in Rats

Basit Öğe Kaydı
dc.authoridKaraduman, Zekeriya Okan/0000-0002-6719-3666
dc.authoridArican, Mehmet/0000-0002-0649-2339
dc.authoridGamsizkan, Mehmet/0000-0001-9942-4898
dc.authoridcelik, mucahit/0009-0004-0187-8525
dc.authoridUludag, Veysel/0000-0002-9911-5961
dc.authoridturhan, yalcin/0000-0002-1440-9566
dc.authoridSaglam, Sonmez/0000-0003-2651-8003
dc.contributor.authorCelik, Mucahit
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorTurhan, Yalcin
dc.contributor.authorArican, Mehmet
dc.contributor.authorGamsizkan, Mehmet
dc.contributor.authorSaglam, Sonmez
dc.contributor.authorUludag, Veysel
dc.date.accessioned2025-10-11T20:47:40Z
dc.date.available2025-10-11T20:47:40Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: Fracture healing or nonunion refers to a process in which many factors interact. In this study, we aimed to evaluate the radiological, histological, and biomechanical effects of phenyramidol and diclofenac, which are frequently used to treat post-fracture ture pain worldwide, on fracture healing and nonunion in a rat femur fracture model. Methods: In this study, 72 male Wistar-Albino rats aged 2-3 months and weighing 250 +/- 30 g were divided into 4 main groups. The rats were divided into 12 subgroups according to the early, middle, and late periods. A fracture model was created in rat femurs, and surgical fixation was performed. Postoperative analgesic treatment protocols included phenyramidol, diclofenac, phenyramidol + diclofenac, and the control group. The rats were sacrificed on the fifteenth, thirtieth, and forty-fifth days and were evaluated radiologically, histopathologically, and biomechanically. Results: Scoring was conducted independently by 2 orthopedists not involved in the study. When the results were analyzed statistically, no statistically significant difference was observed between the fifteenth and thirtieth day radiology score values of the control, diclofenac, phenyramidol, and Phenyramidol + diclofenac groups (p > 0.05), but there was a statistically significant difference (p < 0.05) between the forty-fifth day radiology score values of the control, diclofenac, phenyramidol, and phenyramidol + diclofenac groups. Conclusions: Our study shows that the use of diclofenac or phenyramidol alone negatively affects postoperative fracture healing. However, this effect was less pronounced in the combined treatment group. Histologic examination revealed that neither treatment had a significant effect on healing. There were statistical differences in biomechanical and radiologic properties between the phenyramidol and diclofenac groups; in particular, the diclofenac group had lower biomechanical properties.en_US
dc.identifier.doi10.4055/cios24056
dc.identifier.endpage844en_US
dc.identifier.issn2005-291X
dc.identifier.issn2005-4408
dc.identifier.issue5en_US
dc.identifier.pmid39364103en_US
dc.identifier.scopus2-s2.0-85205605244en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage836en_US
dc.identifier.urihttps://doi.org/10.4055/cios24056
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21514
dc.identifier.volume16en_US
dc.identifier.wosWOS:001343614700020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Orthopaedic Assocen_US
dc.relation.ispartofClinics in Orthopedic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectFracture healingen_US
dc.subjectPhenyramidolen_US
dc.subjectDiclofenacen_US
dc.subjectRaten_US
dc.titleThe Effects of Phenyramidol and Diclofenac Treatment on Fracture Healing in Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu