Antibacterial Activity of Boron Compounds Against Biofilm-Forming Pathogens

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dc.authoridAbd El-Aty, A. M./0000-0001-6596-7907en_US
dc.authoridugras, serpil/0000-0002-1867-5781en_US
dc.authoridKoldemir-Gündüz, Meliha/0000-0003-0969-6377en_US
dc.authoridÇelebi, Özgür/0000-0003-4578-9474en_US
dc.authoridaydın, elif/0000-0003-0877-453Xen_US
dc.authoridBaşer, Sümeyye/0000-0003-2391-8191en_US
dc.authoridAGYAR YOLDAS, PINAR/0000-0002-9277-0648en_US
dc.authorscopusid24068544300en_US
dc.authorscopusid8548683900en_US
dc.authorscopusid57832679500en_US
dc.authorscopusid58296767000en_US
dc.authorscopusid57225152955en_US
dc.authorscopusid54397548800en_US
dc.authorscopusid57452289100en_US
dc.authorwosidAbd El-Aty, A. M./H-8216-2018en_US
dc.authorwosidugras, serpil/KSM-3256-2024en_US
dc.authorwosidÇelebi, Özgür/HMV-9933-2023en_US
dc.authorwosidKoldemir-Gündüz, Meliha/ACE-8842-2022en_US
dc.authorwosidaydın, elif/ACZ-6236-2022en_US
dc.authorwosidBaşer, Sümeyye/ADE-5183-2022en_US
dc.contributor.authorCelebi, Ozgur
dc.contributor.authorCelebi, Demet
dc.contributor.authorBaser, Sumeyye
dc.contributor.authorAydin, Elif
dc.contributor.authorRakici, Erva
dc.contributor.authorUgras, Serpil
dc.contributor.authorYoldas, Pinar Agyar
dc.date.accessioned2024-08-23T16:07:04Z
dc.date.available2024-08-23T16:07:04Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThis study aimed to evaluate the antibacterial activity of nine boron derivatives against biofilm-forming pathogenic bacteria. The effect of boron derivatives (CMB, calcium metaborate; SMTB, sodium metaborate tetrahydrate; ZB, zinc borate; STFB, sodium tetra fluorine borate; STB, sodium tetraborate; PTFB, potassium tetra fluor borate; APTB, ammonium pentabo-rate tetrahydrate; SPM, sodium perborate monohydrate; Borax, ATFB, ammonium tetra fluorine borate) on bacteria isolated from blood culture was determined by the minimum inhibitory concentration (MIC) method. Then, biofilm formation potentials on microplates, tubes, and Congo red agar were examined. The cytotoxicity of boron derivatives was determined by using WST-1-based methods. The interaction between the biofilm-forming bacteria, fibroblast cells, and boron derivatives was determined with the infection model. We found that the sodium metaborate tetrahydrate molecule was effective against all pathogens. According to the optical density values detected at 630 nm in microplates, meticillin-resistant Staphylococcus aureus was observed to have the most substantial biofilm ability at 0.257 nm. As a result of cytotoxicity studies, it has been determined that a 1 & mu;g/L concentration of boron derivatives is not toxic to fibroblast L929 cells. In cell culture experiments, these boron derivatives have very serious inhibitory activity against biofilm-forming pathogens in a short treatment period, such as 2-4 h. Furthermore, using these molecules on inanimate surfaces affected by biofilms would be appropriate instead of living cells.en_US
dc.identifier.doi10.1007/s12011-023-03768-z
dc.identifier.endpage359en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid37464169en_US
dc.identifier.scopus2-s2.0-85165017150en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage346en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-023-03768-z
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14470
dc.identifier.volume202en_US
dc.identifier.wosWOS:001032597300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial activityen_US
dc.subjectBiofilmen_US
dc.subjectBoron derivativesen_US
dc.subjectCell cultureen_US
dc.subjectMinimum inhibitory concentrationen_US
dc.subjectKlebsiella-Pneumoniae Strainsen_US
dc.subjectEscherichia-Colien_US
dc.subjectHigh Prevalenceen_US
dc.subjectInfectionsen_US
dc.subjectVirulenceen_US
dc.subjectSusceptibilityen_US
dc.subjectMechanismsen_US
dc.subjectDiagnosisen_US
dc.subjectK1en_US
dc.subjectK2en_US
dc.titleAntibacterial Activity of Boron Compounds Against Biofilm-Forming Pathogensen_US
dc.typeArticleen_US

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