Association of mean Platelet volume with DSM-IV major depression in a large community-based population: The MELEN study

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dc.contributor.authorCanan, Fatih
dc.contributor.authorDikici, Süber
dc.contributor.authorKutlucan, Ali
dc.contributor.authorCelbek, Gökhan
dc.contributor.authorCoşkun, Hülya
dc.contributor.authorGüngör, Adem
dc.contributor.authorKocaman, Gülşen
dc.date.accessioned2020-04-30T22:39:54Z
dc.date.available2020-04-30T22:39:54Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000301760300004en_US
dc.descriptionPubMed: 22154758en_US
dc.description.abstractThe relationship between major depression and increased platelet activity has been previously stated by several studies. This study sought to test the relationship between mean platelet volume (MPV) - an indicator of platelet activity - and major depression, in an adult Turkish population sample. Respondents were 2286 participants interviewed in a regional survey. The diagnosis of current (one month) major depression was made according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. MPV was measured along with total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, BMI, and waist circumference. Two hundred eighty-nine participants (12.5%) were diagnosed as having major depression. Patients with major depression were found to have increased MPV levels in comparison with participants without depression (p = 0.001). After excluding the subjects with risk factors capable of influencing platelet activity. MPV was still found to be elevated in patients with major depression compared with non-depressed individuals (p < 0.01). Linear regression analysis revealed a significant independent association of major depression with MPV levels (r = 0.123: p = 0.001). According to the findings of this study, increased MPV (or platelet activation) is associated with current (one month) diagnosis of major depression. Future research should investigate the effect of depression treatment on MPV. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpsychires.2011.11.016en_US
dc.identifier.endpage302en_US
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2011.11.016
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2855
dc.identifier.volume46en_US
dc.identifier.wosWOS:000301760300004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Psychiatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor depressionen_US
dc.subjectMean platelet volumeen_US
dc.subjectPlatelet activityen_US
dc.titleAssociation of mean Platelet volume with DSM-IV major depression in a large community-based population: The MELEN studyen_US
dc.typeArticleen_US

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