Prostaglandin E1 maintains structural integrity of intestinal mucosa and prevents bacterial translocation during experimental obstructive jaundice

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dc.contributor.authorGürleyik, Emin
dc.contributor.authorCoşkun, Özgür
dc.contributor.authorÜstündağ, Nil
dc.contributor.authorÖztürk, Elif
dc.date.accessioned2020-04-30T23:21:49Z
dc.date.available2020-04-30T23:21:49Z
dc.date.issued2006
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000240435700003en_US
dc.descriptionPubMed: 16966206en_US
dc.description.abstractThe absence of bile in the gut lumen induces mucosal injury and promotes bacterial translocation (BT). Prostaglandin E (PGE) has a protective effect on the mucosal layer of the alimentary tract. We hypothesize that PGE1 may prevent BT by its beneficial action on the mucosa of the small bowel. Thirty Wistar albino rats were divided equally into 3 groups; Group 1 ( control) underwent sham laparotomy, group 2 obstructive jaundice (OJ) and group 3 ( OJ + PGE1) underwent common bile duct (CBD) ligation and transection. Groups 1 and 2 received; 1 mL normal saline and group 3 received 40 mg of the PGE1 analogue misoprostol dissolved in 1 mL normal saline administered by orogastric tube once daily. After 7 days, laparotomy and collection of samples for laboratory analyses were performed, including bacteriological analysis of intestine, mesenteric lymph nodes (MLNs), and blood, and histopathologic examination of intestinal mucosa to determine mucosal thickness and structural damage. Serum bilirubin and alkaline phosphatase levels confirmed OJ in all animals with CBD transection. The mucosal damage score was significantly reduced in jaundiced animals receiving PGE1 compared to jaundiced controls (2.15 +/- 0.74 vs 5.3 +/- 0.59; p <.00001) and mucosal thickness was greater ( 607 +/- 59.1 mu m vs. 393 +/- 40.3 mu m; p <.00001). The incidence of BT to MLNs decreased from 90% to 30% ( p <.02) when jaundiced rats received PGE1. PGE1 treatment reduced the detection rate of viable enteric bacteria in the blood from 60% to 10% ( p <.057). We conclude that administration of PGE1 provides protection against OJ-induced atrophy and damage of intestinal mucosa, and thereby prevents translocation of enteric bacteria to underlying tissues.en_US
dc.identifier.doi10.1080/08941930600889391en_US
dc.identifier.endpage289en_US
dc.identifier.issn0894-1939
dc.identifier.issue5en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.1080/08941930600889391
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4255
dc.identifier.volume19en_US
dc.identifier.wosWOS:000240435700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbacterial translocationen_US
dc.subjectmisoprostolen_US
dc.subjectobstructive jaundiceen_US
dc.subjectprostaglandin E1en_US
dc.subjectsmall bowel mucosaen_US
dc.titleProstaglandin E1 maintains structural integrity of intestinal mucosa and prevents bacterial translocation during experimental obstructive jaundiceen_US
dc.typeArticleen_US

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