Lack of association between the IL1A gene (-889) polymorphism and outcome after head injury

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dc.contributor.authorTanrıverdi, Taner
dc.contributor.authorUzan, Mustafa
dc.contributor.authorSanus, Galip Zihni
dc.contributor.authorBaykara, Onur
dc.contributor.authorİş, Merih
dc.contributor.authorÖzkara, Çiğdem
dc.contributor.authorBuyra, N.
dc.date.accessioned2020-04-30T23:18:50Z
dc.date.available2020-04-30T23:18:50Z
dc.date.issued2006
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionBuyru, Nur/0000-0002-6920-1455; Baykara, Onur/0000-0002-9754-8456; Uzan, Mustafa/0000-0001-7214-380X; Sanus, Galip Zihni/0000-0001-6539-7254en_US
dc.descriptionWOS: 000234773600003en_US
dc.descriptionPubMed: 16378839en_US
dc.description.abstractBackground: Interleukin (IL) I is a proinflammatory cytokine that has been identified as an important mediator of neurodegeneration induced by ischemia or traumatic brain injury. Accumulating evidence to date has suggested that the major cytokine contributing to neurodegeneration after head injury is IL-1 beta rather than IL-1 alpha; however, there is no sufficient data regarding IL-1 alpha in literature, and there may be an association between IL1A gene polymorphism and outcome after head injury. Methods: We performed a prospective clinical study and included a recruited series of 71 patients who had head injury and were admitted to our neurosurgical unit. Severity of initial injury was assessed by the Glasgow Coma Scale. Outcome at 6 months after injury was assessed by means of the Glasgow Outcome Score. Interleukin la genotypes were determined from blood samples by standard methods. Results: Of 40 patients with ILIA*2, 18 (45%) had an unfavorable outcome (dead, vegetative state, or severe disability) compared with 7 (22.5%) of 31 without ILIA*2 (P =.08). Conclusion: Our findings show that there is no genetic association between ILIA gene polymorphism and outcome after head injury. Further clinical studies should be designed to confirm and further evaluate these findings. (c) 2006 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.surneu.2005.05.024en_US
dc.identifier.endpage10en_US
dc.identifier.issn0090-3019
dc.identifier.issue1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1016/j.surneu.2005.05.024
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3545
dc.identifier.volume65en_US
dc.identifier.wosWOS:000234773600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofSurgical Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytokineen_US
dc.subjecthead injuryen_US
dc.subjectinterleukin 1 alphaen_US
dc.subjectoutcomeen_US
dc.titleLack of association between the IL1A gene (-889) polymorphism and outcome after head injuryen_US
dc.typeArticleen_US

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