Serum uric acid and lipid levels while taking topiramate for migraine
Yükleniyor...
Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective.-Topiramate (TPM) therapies for epilepsy or migraine are long-time therapies with unknown mechanisms and special side effects. TPM influences cholesterol (TC) and lipoprotein serum levels. In addition, TPM may cause uric acid (UA) stone formation. Material and Methods.-Serum UA, TC, and triglyceride (TG) levels were measured in 53 migraine patients receiving TPM and in 44 age- and sex-matched controls. Compared with controls, patients on TPM showed significantly higher UA and nonsignificantly higher TC and TG values. We recorded pre- and posttreatment levels of UA, TC, and TG levels in 23 patients. Results.-We found increased serum levels of UA with TPM use (P < .01). There was a significant and positive correlation between serum UA levels and male gender (P < .01).The changes in serum UA levels before and after TPM treatment differed significantly (P < .01). Conclusion.-Our results suggest a need for monitoring serum UA levels in patients receiving TPM. We should perhaps prescribe a low-UA diet and advice to drink much more water in these patients.
Açıklama
Kocer, Abdulkadir/0000-0003-2866-555X
WOS: 000257483200008
PubMed: 18179568
WOS: 000257483200008
PubMed: 18179568
Anahtar Kelimeler
uric acid, cholesterol, triglyceride, topiramate, migraine, antiepileptic treatment
Kaynak
Headache
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
48
Sayı
7
