Effects of Photodynamic Therapy With Verteporfin for the Treatment of Chronic Central Serous Chorioretinopathy: An Uncontrolled, Open-Label, Observational Study

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dc.contributor.authorSakalar, Yıldırım Bayezit
dc.contributor.authorKeklikçi, Uğur
dc.contributor.authorÜnlü, Kaan
dc.contributor.authorAlakuş, Mehmet Fuat
dc.contributor.authorKara, İsmail Hamdi
dc.date.accessioned2020-05-01T09:12:01Z
dc.date.available2020-05-01T09:12:01Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKARA, ISMAIL HAMDI/0000-0003-2022-1882; KARA, ISMAIL HAMDI/0000-0003-2022-1882en_US
dc.descriptionWOS: 000280083100004en_US
dc.descriptionPubMed: 24683263en_US
dc.description.abstractBACKGROUND: Central serous chorioretinopathy is an idiopathic disorder that leads to serous neurosensory retinal detachment. The disorder is usually self-limited and resolves spontaneously; however, sometimes neurosensory retinal detachment persists. This form of the disorder is called chronic central serous chorioretinopathy (CCSC). OBJECTIVE: The aim of this study was to assess the effects of photodynamic therapy (PDT) on visual acuity with full-dose verteporfin for CCSC. METHODS: The eyes of patients with CCSC were included in the study. Ophthalmic examination including best-corrected visual acuity (BCVA), fundus examination, fluorescein angiography, and optical coherence tomography was performed before treatment and at 1, 3, 6, 9, and 12 months. PDT with full-dose verteporfin (6 mg/m(2) of body surface area) was applied only to areas of active leakage. BCVA was converted to a log of the minimum angle of resolution (logMAR) equivalent for statistical analysis. Central foveal thickness and BCVA between baseline and follow-up were compared. RESULTS: Seventeen eyes of 16 patients (13 males, 3 females; mean [SD] age, 39.75 [7.51] years; mean duration of follow-up, 13.06 [1.82] months) were used in the study. The mean (SEM) logMAR BCVA was 0.26 (0.07) at baseline and 0.04 (0.02) at 12 months. Mean logMAR BCVA values at baseline (0.259) and after treatment (0.112, 0.053, 0.047, 0.041, and 0.041 at 1, 3, 6, 9, and 12 months, respectively) differed significantly (P = 0.006, P = 0.005, P = 0.005, P = 0.005, and P = 0.005). There was a significant difference in the mean central foveal thickness at the final visit (169 pm) compared with the baseline value (383 pm; P < 0.001). BCVA decreased in one eye (20/20 vs 20/25) and persisted during follow-up; in the other 16 eyes, BCVA either increased (n = 10) or remained stable (n = 6). CONCLUSIONS: In this small, open-label study, patients with CCSC treated with a single course of PDT with full-dose verteporfin had significant improvement from baseline in BCVA and resolution of subretinal fluid accumulation and active leakage. Treatment was generally well tolerated, but one patient had worsening in BCVA. (Curr Thor Res Clin Exp. 2010;71:173-185) (C) 2010 Excerpta Medica Inc.en_US
dc.identifier.doi10.1016/j.curtheres.2010.04.002en_US
dc.identifier.endpage185en_US
dc.identifier.issn0011-393X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2010.04.002
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5850
dc.identifier.volume71en_US
dc.identifier.wosWOS:000280083100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical And Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcentral serous chorioretinopathyen_US
dc.subjectphotodynamic therapyen_US
dc.subjectoptical coherence tomographyen_US
dc.subjectverteporfinen_US
dc.titleEffects of Photodynamic Therapy With Verteporfin for the Treatment of Chronic Central Serous Chorioretinopathy: An Uncontrolled, Open-Label, Observational Studyen_US
dc.typeArticleen_US

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