Efficacy of Nebivolol on Flow-Mediated Dilation in Patients With Slow Coronary Flow

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dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorOrdu, Serkan
dc.contributor.authorYüksel, Hatice
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorYazgan, Ömer
dc.contributor.authorYazıcı, Mehmet
dc.date.accessioned2020-05-01T09:12:07Z
dc.date.available2020-05-01T09:12:07Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000271304100001en_US
dc.descriptionPubMed: 19809204en_US
dc.description.abstractSlow coronary flow (SCF) is the phenomenon of slow progression of angiographic contrast in the coronary arteries in the absence of stenosis in the epicardial vessels in some patients presenting with chest pain. There are no definite treatment modalities for patients with SCF. Our aim was to investigate the efficacy of nebivolol in patients with slow coronary flow by monitoring its effects on endothelial function and different markets of inflammation. Forty-two patients (16 females, 26 males mean age, 55 10) with slow coronary flow (SCF) were included in the study. After baseline assessment, the patients were administered nebivolol 5 mg once daily. After 12 weeks of nebivolol therapy, the biochemical and ultrasonographic examinations were repeated. Chest pain relief wits detected in 38 patients after treatment (90%). Systolic and diastolic blood pressure and high sensitive CRP were significantly decreased after nebivolol therapy. Among brachial artery dilation variables that reflect endothelial function, basal resistive index (RI), post-flow mediated dilation RI, and post-nitrate mediated dilation RI were significantly decreased after therapy. Nebivolol is effective at improving endothelial function in patients with SCF. It controls chest pain, decreases CRP, and has favorable effects on brachial artery dilation variables in patients with coronary slow flow. (Int Heart J 2009; 50: 545-553)en_US
dc.identifier.doi10.1536/ihj.50.545en_US
dc.identifier.endpage553en_US
dc.identifier.issn1349-2365
dc.identifier.issn1349-3299
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.1536/ihj.50.545
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5884
dc.identifier.volume50en_US
dc.identifier.wosWOS:000271304100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInt Heart Journal Assocen_US
dc.relation.ispartofInternational Heart Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNebivololen_US
dc.subjectCoronary slow flowen_US
dc.titleEfficacy of Nebivolol on Flow-Mediated Dilation in Patients With Slow Coronary Flowen_US
dc.typeArticleen_US

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