Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia

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dc.contributor.authorAk, Halil
dc.contributor.authorAy, Bahadır
dc.contributor.authorTanrıverdi, Taner
dc.contributor.authorSanus, Galip Zihni
dc.contributor.authorİş, Merih
dc.contributor.authorSar, Mehmet
dc.contributor.authorUzan, Mustafa
dc.date.accessioned2020-05-01T12:10:02Z
dc.date.available2020-05-01T12:10:02Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionUzan, Mustafa/0000-0001-7214-380X; Sanus, Galip Zihni/0000-0001-6539-7254en_US
dc.descriptionWOS: 000249375100004en_US
dc.descriptionPubMed: 17482840en_US
dc.description.abstractRecent arouse of interest indicated that drug resistant proteins are markedly over-expressed in the epileptogenic tissue and they may be responsible for the one-third of the epileptic patients who were refractory to anti-epileptic drugs (AEDs). Since several AEDs may act as substrates for these drug resistant proteins, the enhanced function of such proteins may increase drug extrusion, resulting in inadequate response to drug therapy in patients with epilepsy. We studied expression of the muttidrug resistance protein 1 (MDR1) and muttidrug resistance-associated protein 1 (MRP1) in the epileptic tissues resected surgically in 28 patients with focal cortical dyspLasia (FCD) by immunohistochemistry. The results were compared with 10 normal necropsy brain tissues. Normal brain showed no MDR1 expression in neurons and astrocytes, while MRP1 expression was very weak, which were encountered in a few samples. MDR1 expression was mainly localized on the vascular endothelial cells. In contrast to normal brain, we found intense MDR1 and MRP1 expression in both neurons and reactive astrocytes in the vast majority of dysplastic tissues. The majority of the dysplastic neurons demonstrated moderate to strong MRP1 immunoreactivity. Endothelial cells showed both MDR1 and MRP1 expression in the majority of the specimens studied. Muttidrug transporters are over-expressed in the epiteptogenic zone in patients with FCD. These results are concordant with previous studies, in which over-expression of multidrug proteins were shown in epiteptogenic brain tissue in patients with FCD, that the over-expression of drug transport proteins in tissue from patients with refractory epilepsy may explain one possible mechanism for drug resistant in these pathologies. (c) 2007 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.seizure.2007.03.011en_US
dc.identifier.endpage503en_US
dc.identifier.issn1059-1311
dc.identifier.issn1532-2688
dc.identifier.issue6en_US
dc.identifier.startpage493en_US
dc.identifier.urihttps://doi.org/10.1016/j.seizure.2007.03.011
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5933
dc.identifier.volume16en_US
dc.identifier.wosWOS:000249375100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofSeizure-European Journal Of Epilepsyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectepilepsyen_US
dc.subjectmultidrug resistanceen_US
dc.subjectproteinsen_US
dc.subjectMDR1en_US
dc.subjectMRP1en_US
dc.titleExpression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasiaen_US
dc.typeArticleen_US

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