Effects of topiramate on neurophysiological and neuropsychological tests in migraine patients

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dc.contributor.authorKeçeci, Hulusi
dc.contributor.authorAtakay, Selçuk
dc.date.accessioned2020-05-01T09:12:06Z
dc.date.available2020-05-01T09:12:06Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000271917800009en_US
dc.descriptionPubMed: 19793661en_US
dc.description.abstractTopiramate (TPM) is a antiepileptic drug that has multiple mechanisms of action. It is effective as a monotherapy for migraine prophylaxis. Unfortunately, TPM can frequently cause adverse effects, such as cognitive dysfunction. The present study examines the neuropsychological and neurophysiological effects of TPM in 35 consecutive migraine patients above 18 years of age. The TPM dose was started at 25 mg/day and increased by 25 mg/week, until reaching the maximum dose of 50 mg twice daily in the fourth week. Patients were evaluated for development of side effects of the medication and for its effectiveness on migraine. The Wechsler memory scale was used for neuropsychological evaluation and cognitive evoked potentials were used for neurophysiologic evaluations. Analyses of repeated measures show that visual analog scale pain values, as well as migraine attack frequency and headache duration, were decreased significantly during the study. The amplitudes and latencies of P300 did not change. The results of this study show that 100 mg TPM is effective in the prevention of migraine headache and in reducing severity of attacks. Patients' cognitive complaints are frequent in the first month and decrease in the following month. Despite these complaints, only the attention section of the visual memory section of the Wechsler memory scale was affected - other sections were not affected. Also, P300 study did not reflect changes appropriate to these cognitive complaints. (C) 2009 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2009.03.025en_US
dc.identifier.endpage1591en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1588en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2009.03.025
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5874
dc.identifier.volume16en_US
dc.identifier.wosWOS:000271917800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal Of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectTopiramateen_US
dc.subjectP300en_US
dc.subjectERPen_US
dc.titleEffects of topiramate on neurophysiological and neuropsychological tests in migraine patientsen_US
dc.typeArticleen_US

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