Highly Efficient and Reusable Pd/AlO(OH) Catalyzed Synthesis of Acridinedione Derivatives

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dc.contributor.authorKılbaş, Benan
dc.contributor.authorErgen, Sinem
dc.contributor.authorÇakıcı, Davut
dc.date.accessioned2020-05-01T12:10:22Z
dc.date.available2020-05-01T12:10:22Z
dc.date.issued2019
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionColeri, Sinem/0000-0002-7502-3122; KILBAS, Benan/0000-0002-2478-9312en_US
dc.descriptionWOS: 000484686900007en_US
dc.description.abstractBackground: Synthesis of acridinedione derivatives via one-pot multi-component approaches using highly active and reusable Pd/AlO(OH) heterogenous catalyst was studied. This process provided a convenient method to obtain various acridinediones with potential biological activities. The reactions were performed in mild conditions such as low temperature and short reaction time with desirable yields. Methods: Commercially available Pd/AlO(OH) nanoparticles characterized by XRD and SEM methods were afforded for the synthesis of acridinedione derivatives with high yields. Crude products were analyzed by GC and H-1 NMR. The reactions were completed within 1h at 40 degrees C by the assistance of ultrasound system. Results: Optimization of reaction conditions is of critical case for successful synthesis. Solvent, temperature, time and amount of catalyst were studied. At the end of the experiments, the synthesis of 1 mmol of acridinedione was optimized by using 25 mg of Pd/AlO(OH) NPs, 3 ml of DMF for 60 min at 40 degrees C in the ultrasound system. An experimental work to check the reusability of the catalyst was also studied. Pd/Al(O) OH catalyst in the first run was higher than that of the reused catalyst in the fifth run. ICP-OES analyses showed palladium leaching into the reaction medium was only 1.1% which is negligible. Nanocatalyst employed a high activity and good reusability. Conclusion: A convenient and versatile method was developed for the synthesis of acridinediones in a mild condition with absolute conversion and high yield using ultrasound system in the presence of nanocatalyst.en_US
dc.description.sponsorshipTubitakTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113M941]en_US
dc.description.sponsorshipMoltek A.S and Tubitak financially contributed to this work (grant. no: 113M941).en_US
dc.identifier.doi10.2174/2213337206666190701130253en_US
dc.identifier.endpage265en_US
dc.identifier.issn2213-3372
dc.identifier.issn2213-3380
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.2174/2213337206666190701130253
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6168
dc.identifier.volume6en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Organocatalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcridinedioneen_US
dc.subjectaldehydeen_US
dc.subjectdimedoneen_US
dc.subjectheterogeneous catalysten_US
dc.subjectmulticomponent reactionen_US
dc.subjectultrasound systemen_US
dc.titleHighly Efficient and Reusable Pd/AlO(OH) Catalyzed Synthesis of Acridinedione Derivativesen_US
dc.typeArticleen_US

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