Highly Efficient and Reusable Pd/AlO(OH) Catalyzed Synthesis of Acridinedione Derivatives
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Kılbaş, Benan
Ergen, Sinem
Çakıcı, Davut
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bentham Science Publ Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Synthesis of acridinedione derivatives via one-pot multi-component approaches using highly active and reusable Pd/AlO(OH) heterogenous catalyst was studied. This process provided a convenient method to obtain various acridinediones with potential biological activities. The reactions were performed in mild conditions such as low temperature and short reaction time with desirable yields. Methods: Commercially available Pd/AlO(OH) nanoparticles characterized by XRD and SEM methods were afforded for the synthesis of acridinedione derivatives with high yields. Crude products were analyzed by GC and H-1 NMR. The reactions were completed within 1h at 40 degrees C by the assistance of ultrasound system. Results: Optimization of reaction conditions is of critical case for successful synthesis. Solvent, temperature, time and amount of catalyst were studied. At the end of the experiments, the synthesis of 1 mmol of acridinedione was optimized by using 25 mg of Pd/AlO(OH) NPs, 3 ml of DMF for 60 min at 40 degrees C in the ultrasound system. An experimental work to check the reusability of the catalyst was also studied. Pd/Al(O) OH catalyst in the first run was higher than that of the reused catalyst in the fifth run. ICP-OES analyses showed palladium leaching into the reaction medium was only 1.1% which is negligible. Nanocatalyst employed a high activity and good reusability. Conclusion: A convenient and versatile method was developed for the synthesis of acridinediones in a mild condition with absolute conversion and high yield using ultrasound system in the presence of nanocatalyst.
Açıklama
Coleri, Sinem/0000-0002-7502-3122; KILBAS, Benan/0000-0002-2478-9312
WOS: 000484686900007
WOS: 000484686900007
Anahtar Kelimeler
Acridinedione, aldehyde, dimedone, heterogeneous catalyst, multicomponent reaction, ultrasound system
Kaynak
Current Organocatalysis
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
6
Sayı
3
