Predictive value of nutritional scores in non-valvular atrial fibrillation patients: Insights from the AFTER-2 study

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dc.authoridSoner, Serdar/0000-0002-2807-6424;
dc.contributor.authorSoner, Serdar
dc.contributor.authorGuzel, Tuncay
dc.contributor.authorAktan, Adem
dc.contributor.authorKilic, Raif
dc.contributor.authorArslan, Bayram
dc.contributor.authorDemir, Muhammed
dc.contributor.authorGuzel, Hamdullah
dc.date.accessioned2025-10-11T20:48:28Z
dc.date.available2025-10-11T20:48:28Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground and aim: Many scoring systems are used to evaluate malnutrition, but there is no consensus on which scoring system would be more appropriate. We aimed to investigate the effect of malnutrition in patients with non-valvular atrial fibrillation (NVAF) and to compare three scoring systems. Methods and results: A total of 2592 patients with non-valvular AF from 35 different centers in Turkey were included in this prospective study. All participants were divided into two groups: 761 patients who died and 1831 patients who were alive. The malnutrition status of all participants was evaluated with three scoring systems. The primary outcome was all-cause mortality. The mean age of the population was 68.7 +/- 11.1 years, and 55.5 % were female. According to Cox regression analysis, the geriatric nutritional risk index (GNRI) (HR = 0.989, 95 % CI: 0.982-0.997, p = 0.007), controlling nutritional status (CONUT) score (HR = 1.121, 95 % CI: 1.060-1.185, p < 0.001), and prognostic nutritional index (PNI) (HR = 0.980, 95 % CI: 0.962-0.999, p = 0.036) were found to be significant mortality predictors. ROC curve analysis indicated GNRI (AUC = 0.568), CONUT (AUC = 0.572), and PNI (AUC = 0.547) had moderate predictive values. Kaplan-Meier analysis showed that increasing the risk class based on GNRI (p < 0.001) and CONUT (p < 0.001) was associated with decreased survival, while PNI staging had no statistically significant effect (p = 0.266). Conclusions: Malnutrition, determined by three scoring systems, was found to be an independent predictor of all-cause mortality in NVAF patients. Nutritional examination may provide useful information for prognosis and risk stratification in patients with NVAF.en_US
dc.identifier.doi10.1016/j.numecd.2024.103794
dc.identifier.issn0939-4753
dc.identifier.issn1590-3729
dc.identifier.issue3en_US
dc.identifier.pmid39757075en_US
dc.identifier.scopus2-s2.0-85214135176en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.numecd.2024.103794
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21939
dc.identifier.volume35en_US
dc.identifier.wosWOS:001437052600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofNutrition Metabolismand Cardiovascular Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectAtrial fibrillationen_US
dc.subjectMalnutritionen_US
dc.subjectControlling nutritional statusen_US
dc.subjectGeriatric nutritional risk indexen_US
dc.subjectPrognostic nutritional indexen_US
dc.titlePredictive value of nutritional scores in non-valvular atrial fibrillation patients: Insights from the AFTER-2 studyen_US
dc.typeArticleen_US

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