Treatment of critically ill patients with acute hypercarbic respiratory failure by average volume-assured pressure support mode

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dc.authoridAkbas, Turkay/0000-0002-2150-6866
dc.authorwosidAkbas, Turkay/G-4609-2016
dc.contributor.authorAkbas, Turkay
dc.contributor.authorAltun, Gulsah
dc.date.accessioned2021-12-01T18:46:59Z
dc.date.available2021-12-01T18:46:59Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractObjectives Average volume-assured pressure support (AVAPS), a dual mode, delivers a set tidal volume (TV) per kg by adjusting the pressure between upper and lower inspiratory positive airway pressures (IPAP). Thus, ventilation is presumed to be happened effectively by sending a guaranteed TV. This study was aimed to evaluate the effectiveness of AVAPS mode in critically ill patients with acute hypercarbic respiratory failure (HRF) and compare the results with bilevel positive airway pressure-spontaneous/timed (BPAP-S/T) mode. Methods Sixty patients were assigned to BPAP-S/T (n = 29) and AVAPS modes (n = 31). Maximum IPAP was started at 20 cmH(2)O and minimum IPAP was set at 5 cmH(2)O higher than expiratory positive airway pressure (EPAP) in AVAPS mode. IPAP was started at 15 cmH(2)O in BPAP-S/T mode. IPAP levels were titrated up to 30 cmH(2)O during noninvasive mechanic ventilation (NIMV) with a targeted TV of 6-8 mL/kg. Patients were followed for 5 days. Results No differences were found in pH, paCO(2), HCO3, TV and EPAP between the two groups when compared separately by days. Maximum IPAP levels were significantly high in AVAPS mode in all times (P < 0.001). The length of stay (LOS) in intensive care unit (ICU) (P = 0.994) and hospital (P = 0.509), hours of NIMV use per day (P = 0.101) and NIMV success rate (P = 0.931) were identical between the two groups. ICU (P = 0.931), hospital (P = 0.800), 6-month (P = 0.919) and 1-year (P = 0.645) mortality rates were also not different between the both groups. Conclusions AVAPS mode had similar efficiency with BPAP-S/T mode regarding the NIMV treatment success in critically ill patients with acute HRF.en_US
dc.description.sponsorshipDuzce University Scientific Research FundDuzce University [BAP-2015.04.03.382]en_US
dc.description.sponsorshipThis work was supported by Duzce University Scientific Research Fund (Grand number: BAP-2015.04.03.382)en_US
dc.identifier.doi10.1111/crj.13401
dc.identifier.endpage982en_US
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue9en_US
dc.identifier.pmid34014046en_US
dc.identifier.scopus2-s2.0-85107160197en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage973en_US
dc.identifier.urihttps://doi.org/10.1111/crj.13401
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10084
dc.identifier.volume15en_US
dc.identifier.wosWOS:000657634500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Respiratory Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjecthypercarbic respiratory failureen_US
dc.subjectmortalityen_US
dc.subjectnoninvasive mechanic ventilationen_US
dc.subjectvolume guaranteed ventilationen_US
dc.subjectObstructive Pulmonary-Diseaseen_US
dc.subjectIntensive-Care-Uniten_US
dc.subjectNoninvasive Ventilationen_US
dc.subjectObesityen_US
dc.subjectExacerbationsen_US
dc.subjectAdjustmenten_US
dc.subjectCopden_US
dc.titleTreatment of critically ill patients with acute hypercarbic respiratory failure by average volume-assured pressure support modeen_US
dc.typeArticleen_US

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