The role of Ga-68-DOTA-TATE PET/CT scanning in the evaluation of patients with multiple myeloma: preliminary results

Basit Öğe Kaydı
dc.contributor.authorSönmezoğlu, Kerim
dc.contributor.authorVatankulu, Betül
dc.contributor.authorElverdi, Tuğrul
dc.contributor.authorAkyel, Reşit
dc.contributor.authorErkan, Melih E.
dc.contributor.authorHalaç, Metin
dc.contributor.authorAydın, Yıldız
dc.date.accessioned2020-04-30T23:34:29Z
dc.date.available2020-04-30T23:34:29Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSonmezoglu, Kerim/0000-0003-1215-5184; Demirci, Emre/0000-0002-6387-9089; ELVERDI, TUGRUL/0000-0001-9496-5353; ocak, meltem/0000-0001-9214-3938en_US
dc.descriptionWOS: 000390778600011en_US
dc.descriptionPubMed: 27775994en_US
dc.description.abstractObjectiveIn this observational pilot study, we aimed to evaluate the role of gallium-68-labelled DOTA-TATE (Ga-68-TATE) PET/computed tomography (CT) scanning in patients with multiple myeloma (MM), considering previous promising results obtained from conventional somatostatin receptor scintigraphy with In-111 pentetreotide.Materials and methodsTwenty-one patients with a diagnosis of MM were prospectively included in this study: eight patients were referred for initial staging and 13 patients for restaging purpose. Both fluorine-18 fluorodeoxyglucose (F-18-FDG) and TATE PET/CT scanning were performed in all patients.ResultsAll patients had one or more PET-positive lesion on either F-18-FDG or TATE scans. Six patients had an additional diffusely increased bone marrow activity on F-18-FDG scans, five of whom also had a concordant bone marrow appearance on TATE scans. Each PET set (either F-18-FDG or TATE) was positive in 19 patients. There was a discordant result in four (19%) patients between F-18-FDG and TATE scans. F-18-FDG scans showed 112 lesions (86 TATE-positive; 26 TATE-negative) in 19 patients, whereas TATE scans showed 108 lesions (86 F-18-FDG-positive; 22 F-18-FDG-negative) in 19 patients. No significant difference was found between the two modalities in terms of lesion numbers detected (P=0.67). However, the presence of diffuse bone marrow uptake of TATE seems to be a predicting factor for the overall survival (P=0.033, hazard ratio: 15.2 and 95% confidence interval: 1.2-185.5).ConclusionTATE PET/CT seems to be an alternative imaging modality and may play a complementary role in MM management, at least by providing a different pathobiological insight into the disease.en_US
dc.identifier.doi10.1097/MNM.0000000000000610en_US
dc.identifier.endpage83en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.1097/MNM.0000000000000610
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5173
dc.identifier.volume38en_US
dc.identifier.wosWOS:000390778600011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgallium-68 DOTA-TATEen_US
dc.subjectfluorine-18 fluorodeoxyglucoseen_US
dc.subjectmultiple myelomaen_US
dc.subjectPETen_US
dc.subjectCTen_US
dc.subjectplasmacytomaen_US
dc.subjectsomatostatin receptor scintigraphyen_US
dc.titleThe role of Ga-68-DOTA-TATE PET/CT scanning in the evaluation of patients with multiple myeloma: preliminary resultsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5173.pdf
Boyut:
263.16 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu