The Predictive Role of a Novel Risk Index in Patients Undergoing Carotid Artery Stenting: Systemic Immune-Inflammation Index

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dc.authoridDogan, Selami/0000-0003-1170-4567
dc.authoridKup, Ayhan/0000-0003-1977-069X
dc.contributor.authorKeskin, Muhammed
dc.contributor.authorOcal, Lutfi
dc.contributor.authorCersit, Sinan
dc.contributor.authorYilmaz, Cemalettin
dc.contributor.authorKup, Ayhan
dc.contributor.authorCelik, Mehmet
dc.contributor.authorTurkmen, Mehmet Muhsin
dc.date.accessioned2021-12-01T18:50:19Z
dc.date.available2021-12-01T18:50:19Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractBackground: Inflammatory mechanisms play an important role in both atherosclerosis and stroke. There are several inflammatory peripheral blood count markers associated with carotid artery stenosis degree, symptomatic carotid artery lesions and carotid artery stent restenosis that reported in previous studies. However, the prognostic role of the blood cell counts and their ratios in predicting in-hospital and long-term outcomes in patients undergoing carotid artery stenting (CAS) has not been comprehensively investigated. Systemic immune-inflammation index (SII) proved its' efficiency in patients with solid tumors and its' role was rarely examined in cardiovascular disorders and stroke. The current study evaluated the effect of this novel risk index on in-hospital and long-term outcomes in a large patient population who underwent CAS. Method: A total of 732 patients with carotid artery stenosis who underwent CAS were enrolled to the study. SII was calculated using the following formula: neutrophil-to-lymphocyte ratio pound total platelet count in the peripheral blood (per mm3) and the patients were stratified accordingly: T1, T2 and T3. In-hospital and 5-year outcomes were compared between the tertiles of SII. Results: During the hospitalization, major stroke, ipsilateral stoke, myocardial infarction, death and major adverse cardiovascular events (MACE) rates were significantly higher in high SII level (T3) compared to SII levels (T1 and 2). In longterm outcomes, ipsilateral stroke, major stroke, transient ischemic attack, death, and MACE were significantly higher in the patients with higher SII level (T3). The 5-year Kaplan-Meier overall survival for T1, T2, and T3 were 97.5%, 96.7% and 86.0% respectively. In-hospital and 5-year regression analyses demonstrated that high SII was independently associated with MACE and mortality. Conclusion: SII was independently associated with in-hospital and long-term clinical outcomes in patients undergoing CAS. Immune and inflammation status, as assessed easily and quickly using SII, has a good discriminative value in these patients.en_US
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2021.105955
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.issue9en_US
dc.identifier.pmid34242858en_US
dc.identifier.scopus2-s2.0-85109196298en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105955
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10860
dc.identifier.volume30en_US
dc.identifier.wosWOS:000686903400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Stroke & Cerebrovascular Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarotid artery stentingen_US
dc.subjectInflammationen_US
dc.subjectMortalityen_US
dc.subjectStrokeen_US
dc.subjectTransient Ischemic Attacken_US
dc.subjectLymphocyte Ratioen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectClinical Predictorsen_US
dc.subjectHigh Neutrophilen_US
dc.subjectStrokeen_US
dc.subjectEndarterectomyen_US
dc.subjectPlateleten_US
dc.subjectOutcomesen_US
dc.subjectDiseaseen_US
dc.titleThe Predictive Role of a Novel Risk Index in Patients Undergoing Carotid Artery Stenting: Systemic Immune-Inflammation Indexen_US
dc.typeArticleen_US

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