The pituitary-gonadal-thyroid and lactotroph axes in critically ill patients

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dc.contributor.authorAkbaş, Türkay
dc.contributor.authorDeyneli, Oğuzhan
dc.contributor.authorSönmez, Firuze Turan
dc.contributor.authorAkalın, Sema
dc.date.accessioned2020-04-30T23:34:00Z
dc.date.available2020-04-30T23:34:00Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionTURAN SONMEZ, Feruza/0000-0001-8817-8521en_US
dc.descriptionWOS: 000380102000009en_US
dc.descriptionPubMed: 26884301en_US
dc.description.abstractIntroduction: The normal circadian rhythm of hormones in critical patients becomes chaotic causing some hormones to increase and others to decrease abnormally. The goal of this study is to evaluate hormonal changes in severely ill patients and to investigate the relationship between hormonal changes and mortality and morbidity. Material and methods: We enrolled 20 patients (10 F/10 M). Blood samples were collected on day 0, day 5, and day 10. If a patient was discharged before these defined days, a sample was drawn on that day. Twenty healthy controls were included. Results: Female patients had lower LH, FSH, and fT(3) and higher PRL and cortisol levels than controls on admission to the intensive care unit (ICU) (p(LH) = 0.021, p(FsH):0.001, p(f13) = 0.021, p(PRL) = 0.042, p(Cortisol) < 0.001, respectively). Men had significantly low testosterone and fT(3), and high PRL and cortisol levels on ICU admission (p(T) = 0.01, p(fT3) = 0.043, p(PRL) = 0.005, p(Cortisol) < 0.001, respectively). The lowest levels of gonadotropins in both genders and testosterone in men were measured on day 5. Cortisol levels decreased in the patients discharged from the ICU (p = 0.01). FSH levels increased in recovered women (p(FSH) = 0.043). The mortality rate was 30%. There were correlations between admission TSH and NIMV duration (p = 0.006), fT(3) and APACHE II (p = 0.001), and PRL and mortality (p = 0.044). Positive correlations between E-2 and APACHE II (p = 0.003) in females, and PRL and APACHE II (p = 0.022) in males were also displayed. Conclusions: Critically ill patients develop significant changes in neuroendocrine axes. Alterations in hormones correlate with the disease severity and mortality.en_US
dc.identifier.doi10.5603/EP.a2016.0032en_US
dc.identifier.endpage311en_US
dc.identifier.issn0423-104X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.5603/EP.a2016.0032
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5084
dc.identifier.volume67en_US
dc.identifier.wosWOS:000380102000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofEndokrynologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmortalityen_US
dc.subjectneuroendocrine changesen_US
dc.subjectprolactinen_US
dc.subjectsevere illnessen_US
dc.titleThe pituitary-gonadal-thyroid and lactotroph axes in critically ill patientsen_US
dc.typeArticleen_US

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