Modulation of Brain-derived Neurotrophic Factor and Nerve Growth Factor Gene Expression in the Hippocampus and Cortex Regions of Rats with Penicillin-induced Experimental Epilepsy: The Effect of Adenosine Triphosphate-sensitive Potassium Channels

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dc.contributor.authorKilic, Umit
dc.contributor.authorSoyturk, Hayriye
dc.contributor.authorYildiz, Aysegul
dc.contributor.authorOnal, Cansu
dc.date.accessioned2025-10-11T20:47:39Z
dc.date.available2025-10-11T20:47:39Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective:The objective is to investigate the effect of adenosine triphosphate (ATP)-sensitive potassium (KATP) channels on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) gene expression in the hippocampus and cortex regions using a penicillin-induced epilepsy model. Materials and Methods:The study included four groups, control (C), epilepsy (E), epilepsy-opener (E-O), and epilepsy-blocker (E-B), and three subgroups, 1st day, 4th day, and 8th day after the seizure. The hippocampus and cortex were dissected from all animals and BDNF and NGF messenger ribonucleic acid (mRNA) expression levels were quantified using quantitative polymerase chain reaction (qPCR). Results:The relative gene expression of the NGF gene evaluated in hippocampal tissues was found to be significantly higher in the epilepsy 1st-day group compared with the C group (P < 0.05). The relative gene expression of the NGF gene in cortex tissues was found to be significantly higher in the epilepsy 8th-day group compared with the C group (P < 0.05). The relative gene expression of the BDNF gene in hippocampal tissues was also significantly higher in the epilepsy 1st-day group compared with the C group (P < 0.05). BDNF gene expression levels in the cortex region were significantly higher in the E group on the 8th day, in the E-O group on the 1st, 4th, and 8th days, and in the E-B group on the 1st day; BDNF gene expression level was also significantly higher in the E-B group on the 8th day compared with the C group (P < 0.05). Conclusion:KATP channels play a modulatory role in the expression levels of BDNF and NGF genes in the cortex over an extended period of 8 days, parallel to their efficacy observed in the hippocampus on day 1. These mechanisms need to be thoroughly investigated and emphasized due to their importance.en_US
dc.description.sponsorshipBolu Abant Idot;zzet Baysal University Research Foundation [2019.10.01.1408]en_US
dc.description.sponsorshipThis study was financed by the Bolu Abant & Idot;zzet Baysal University Research Foundation (BAP-grant number: 2019.10.01.1408).en_US
dc.identifier.doi10.4103/nsn.nsn_142_24
dc.identifier.endpage21en_US
dc.identifier.issn2636-865X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-105002008094en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://doi.org/10.4103/nsn.nsn_142_24
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21512
dc.identifier.volume42en_US
dc.identifier.wosWOS:001456305100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNeurological Sciencesand Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectAdenosine triphosphate-sensitive potassium channelsen_US
dc.subjectbrain-derived neurotrophic factoren_US
dc.subjectepilepsyen_US
dc.subjectnerve growth factoren_US
dc.titleModulation of Brain-derived Neurotrophic Factor and Nerve Growth Factor Gene Expression in the Hippocampus and Cortex Regions of Rats with Penicillin-induced Experimental Epilepsy: The Effect of Adenosine Triphosphate-sensitive Potassium Channelsen_US
dc.typeArticleen_US

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