Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation

Basit Öğe Kaydı
dc.contributor.authorOnat, Altan
dc.contributor.authorCan, Günay
dc.contributor.authorHergenç, Gülay
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorKarabulut, Ahmet
dc.contributor.authorAlbayrak, Sinan
dc.date.accessioned2020-04-30T23:31:51Z
dc.date.available2020-04-30T23:31:51Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKarabulut, Ahmet/0000-0002-2001-9142en_US
dc.descriptionWOS: 000247487600013en_US
dc.descriptionPubMed: 17299378en_US
dc.description.abstractObjectives: To investigate the role of serum apolipoprotein (apo) B levels in predicting metabolic syndrome (MS), hypertension, atherogenic dyslipidemia and type II diabetes. Methods: Prospective evaluation of 1125 men and 1223 women, aged 28-74 years, participating in the survey 1997/1998 who had serum apo B determinations and were followed-up for a mean 5.9 years. Tertiles of apo B were formed by cut points by 120 and 95 mg/dl. MS was defined by modified ATPIII criteria. Results: Apo B values exhibited no significant difference among sexes. Low-density lipoprotein (LDL)-cholesterol and triglycerides were their leading determinants on linear regression analysis. By logistic regression analyses, the top versus bottom apo B tertile predicted significantly newly developing MS in both sexes separately with two-fold relative risks (RRs) (P<0.02) and the development of high triglyceride/low high-density lipoprotein-cholesterol dyslipidemia with nearly threefold RRs (P=0.001), after adjustment for waist circumference, C-reactive protein (CRP), physical activity grade and family income category. Development of hypertension was predicted only in women by the apo B top tertile (fully adjusted RR 1.71 [95% CI 1.001; 2.92]), while the significance of the prediction regarding age-adjusted diabetes in women (RR 1.86 [95% CI 1.04; 3.36]) attenuated after adjustment for the stated confounding factors. Conclusions: Apo B concentrations, which reflect the number of small, dense LDL particles in plasma, are a significant predictor of cardiometabolic risk among adults with a high prevalence of MS, independent of waist circumference and CRP.en_US
dc.identifier.doi10.1038/sj.ijo.0803552en_US
dc.identifier.endpage1125en_US
dc.identifier.issn0307-0565
dc.identifier.issn1476-5497
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1119en_US
dc.identifier.urihttps://doi.org/10.1038/sj.ijo.0803552
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4500
dc.identifier.volume31en_US
dc.identifier.wosWOS:000247487600013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofInternational Journal Of Obesityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectapolipoprotein Ben_US
dc.subjectcentral obesityen_US
dc.subjectdiabetes mellitusen_US
dc.subjectdyslipidemiaen_US
dc.subjecthypertensionen_US
dc.subjectmetabolic syndromeen_US
dc.titleSerum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammationen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
4500.pdf
Boyut:
97.92 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu