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Öğe Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis(Springer, 2010) Orhan, Zafer; Cevher, Erdal; Yıldız, Ayça; Ahıskalı, Rengin; Şensoy, Demet; Mülazımoğlu, LütfiyeThe aim of this study was to prepare poly(d,l-lactide-co-glycolide) (PLGA) microspherical implants containing teicoplanin (TCP) using a double emulsion solvent evaporation method and to evaluate its efficacy for the local treatment of chronic osteomyelitis. The particle size and distribution, morphological characteristics, thermal behaviour, drug content, encapsulation efficiency and in vitro release assessments of the formulations were carried out. Sterile TCP-PLGA microspheres were implanted in the proximal tibia of rats with methicillin resistant Staphylococcus aureus (MRSA) osteomyelitis. After 3 weeks of treatment, bone samples were analysed with a microbiological assay and evaluated histopathologically. Microspheres between the size ranges of 2.01 and 3.91 mu m were obtained. Production yield of all formulations was found to be higher than 82% and encapsulation efficiencies of 33.6-69.8% were obtained. DSC thermogram showed that the TCP was in an amorphous state in microspheres. In vitro drug release studies had indicated that the drug release rate of microspheres was decreased upon increasing the polymer:drug ratio. Based on the in vivo data, rats treated with implants and intramuscular injection showed 1.7 x 10(3) +/- A 1.3 x 10(3) and 5.8 x 10(4) +/- A 5.3 x 10(4) colony forming unit of MRSA in 1 g bone samples (CFU/g), respectively (P < 0.01). The in vitro and in vivo studies had shown that the TCP-PLGA microspheres were effective for the treatment of chronic osteomyelitis in an animal experimental model. Hence, these microspheres may be potentially useful in the clinical setting with the need for further investigation for optimal dosing of TCP-PLGA microspheres.Öğe Comparison of accuracy of three-dimensional spiral computed tomography, standard radiography, and direct measurements in evaluating facial fracture healing in a rat model(Lippincott Williams & Wilkins, 2004) Özçelik, Derya; Hüthüt, İlkay; Kuran, İsmail; Bankaoğlu, Müjdat; Orhan, Zafer; Mayda, Atilla SenihComplex maxillofacial fractures demand a detailed understanding of the three-dimensional (3D) pattern of injury. Evaluation of the outcome of the facial fracture repair additionally requires optimal demonstration of fracture gap, bony union, fibrous callus or incorporation of fracture ends, presence of incomplete fusion, or pseudoarthrosis. Although 3D computed tomography (CT) is reliably used for the diagnosis of complex facial fractures, its value in facial fracture healing is unknown. An experimental study was conducted to determine the accuracy of 3D spiral CT scans in evaluating facial fracture healing during the early and late postoperative periods. In 10 adult Wistar Albino rats, a standardized bone defect (3 mm) was created within the mid portion of each zygomatic arch (n = 20). At 10 and 20 weeks postfracture, gap distance displayed by 3D CT and plane radiography (posteroanterior) were measured. At 20 weeks postfracture, intraoperative measurement was also performed. A comparison between 3D CT, radiography, and intraoperative findings was performed. At 10 weeks postfracture, the fracture sites displayed larger bone defects in imaging with 3D CT than with plane radiography. The difference between groups was statistically significant (P < 0.05). The mean defect size imaged by 3D CT was 0.91 +/- 0.82 turn (standard deviation) and by plane radiography was 0.42 +/- 0.16 mm. At 20 weeks postfracture, the mean defect size imaged by 3D CT was 0.56 +/- 0.64 mm, and by plane radiography was 0.38 +/- 0.22 mm. The difference between groups was not statistically significant (P > 0.05). The defect size imaged by both plane radiography and 3D CT was significantly less than the measurement obtained from the intraoperative assessment (P < 0.05). It was concluded that 3D CT has limited benefit in the detection of newly formed bone at week 10 and in the detection of fibrous callus, which can eventually give rise to the bony tissue. Plane radiography is more valid during the early postoperative period (week 10), because it can detect the fibrous callus and newly formed bone more precisely. Gap distance between fracture ends could be determined by 3D CT accurately at week 20, although there was a tendency, which was not statistically significant, to overestimate the amount of bone defect measured by 3D CT when compared with that of plane radiography.Öğe Comparison of peripheral nerve repair using ethylcyanoacrylate and conventional suture technique in a rat sciatic nerve injury model(2020) Atam, Camettin; Orhan, Zafer; Toplu, Gaye; Serin, Merdan; Karaduman, Zekeriya Okan; Öztürk, AyhanObjective: The aim of this study was to compare the outcomes of primary nerve repair using either ethyl-cyanoacrylate orconventional microsuture technique in a rat peripheral nerve injury model.Methods: In this study, a total of 30 Wistar Albino rats weighing between 220 and 275 g were used. The rats were randomlydivided into three groups (10 in each), including one control (group 1) and two experimental groups (group 2, conventionalmicrosuture repair; group 3, cyanoacrylate repair). In each group, the sciatic nerve was identified and transected. No furtherintervention was performed in group 1. The nerve was repaired using the epineural technique with a 10/0 atraumaticnylon in group 2 and synthetic cyanoacrylate adhesive in group 3. At the fifth postoperative week, needle electromyography(EMG) was performed to measure distal latency, combined muscle action potential (CMAP), and motor nerve conductionvelocity (MNCV). Following the EMG recordings, animals were euthanized. Nerve samples were collected to evaluate vacuolardegeneration, fibrosis, and foreign body reaction histopathologically.Results: In the EMG analysis, mean distal latency was significantly shorter in group 1 (0.85±0.09 ms) than in groups 2(1.17±0.25 ms) (p=0.0052) and 3 (1.14±0.14 ms) (p=0.0026) while no significant differences existed between groups 2 and3 (p>0.9999). The mean CMAP was greater in group 1 (10.5±0.35 mV) than in groups 2 (2.86±1.28 mV) (p=0.011) and 3(2.16±1.34 mV) (p=0.0002), but there was no significant difference between groups 2 and 3 (p>0.9999). The mean MNCVwas 53.5±5.95, 39.62±7.31, and 39.84±4.73 mm/sec in groups 1, 2, and 3, respectively. There was a significant differencebetween groups 1 and 2 (p=0.0052) and between 1 and 3 (p=0.0026), but not between 2 and 3 (p>0.9999). In the histopathologicalevaluation, the mean vacuolar degeneration score was 0, 2.12, and 1.88 in groups 1, 2, and 3, respectively. No obviousdifference was observed between groups 2 and 3 (p=0.743). The mean fibrosis score was 0, 1.62, and 1.77 in groups 1, 2,and 3, respectively. There was no significant difference between groups 2 and 3 (p=0.888). The mean foreign body reactionscore was 0, 2.5, and 2.44 in groups 1, 2, and 3, respectively. No difference was present between groups 2 and 3 (p=0.743).Conclusion: Primary nerve repair using the cyanoacrylate adhesive may provide similar electrophysiological and histopathologicalresults as compared to the conventional microsuture repair.Öğe A Comparison of the Modified Bosworth and Endobutton Techniques in the Surgical Treatment of Rockwood Type III Acromioclavicular Joint Dislocations(2020) Karaduman, Zekeriya Okan; Orhan, Zafer; Turhan, Yalçın; Arıcan, Mehmet; Değirmenci, Erdem; Turhal, OzanAim: In this study, we aimed to retrospectively compare the long-term clinical and radiological outcomesobtained with the modified Bosworth technique and Endobutton technique in surgical treatment of type IIIacromioclavicular dislocations.Materials and Methods: Thirty-two patients (26 males, 6 females) (mean age 37, range 15–78 years) weretreated surgically for acromioclavicular joint (ACJ) dislocation. All patients had type III dislocation. Twentytwo patients had right ACJ dislocation and 10 patients had left ACJ dislocation. Of the dislocations, 18 occurred due to falls; 9, sports injuries; and 5, traffic accidents. Of the patients, 18 were operated on with theEndobutton technique and 14 with the modified Endobutton technique. Patients were evaluated postoperatively in terms of functional Constant, DASH, and VAS scores and radiologically with coracoclavicular distance(CCD) assessment. The mean follow-up was 52 (37–66) months.Results: The alignment of the acromioclavicular joint was normal in all patients. No joint degeneration wasobserved in any patient. Shoulder movements were painless and complete in all patients. The mean postoperative 3rd, 12th, and 24th month Constant scores were found significantly higher for the Endobutton group thanfor the modified Bosworth group (p=0.001). The mean postoperative 3rd, 12th, and 24th month DASH scoreswere significantly lower for the Endobutton Group than for the modified Bosworth group (p=0.003). Themean postoperative 3rd, 12th, and 24th month VAS scores were significantly lower for the Endobutton groupthan for the modified Bosworth group (p=0.001). However, no statistically significant difference was foundbetween the mean preoperative and postoperative CCD values of the two groups (p=0.104).Discussion and Conclusion: The Endobutton technique is a good alternative to the modified Bosworthtechnique in the surgical treatment of acromioclavicular dislocations.Öğe Diffuse-type giant cell tumor: Pigmented villonodular synovitis of patellar fat pad(Wolters Kluwer Medknow Publications, 2022) Değirmenci, Erdem; Şahin, Abdullah Alper; Bulum, Yunus Emre; Gamsızkan, Mehmet; Orhan, ZaferPigmented villonodular synovitis (PVNS) is a rare, relatively benign intra-articular lesion characterized by slowly progressing proliferation of the synovial tissue. It is most commonly observed in the knee joint. Localized and diffuse types are two types of PVNS depending on the synovial involvement. Arthroscopic and excisional resections are recommended as the treatment methods for the PVNS. Radiotherapy or chemotherapy can be adjuvant therapeutic options for the widespread masses. In this study, we presented a case of diffuse PVNS originating from the patellar fat pad.Öğe Effect of extracorporeal shock wave therapy on fracture healing in rat femural fractures with intact and excised periosteum(Turkish Joint Diseases Foundation, 2014) Oktaş, Birhan; Orhan, Zafer; Erbil, Barış; Değirmenci, Erdem; Üstündağ, NilObjectives: The aim of this study is to compare the effect of extracorporeal shock wave therapy (ESWT) on fractures with intact periosteum and excised periosteum. Materials and methods: Thirty-seven Wistar albino rats were randomized into four groups. Osteotomy and intramedullary Kirschner wire fixation were performed on all right femurs under ketamin anesthesia. The first group (n=10) was identified as control group. In the second group (n=10), periosteum located at the osteotomy site was excised circumferentially during surgery. In the third group (n=9), periosteum was left intact and ESWT was applied. In the forth group (n=8), periosteums of all rats were excised and ESWT was applied. All fracture lines were evaluated radiographically each two weeks and histologically at the sixth week. Results were evaluated statistically. Results: In periosteum excised group which represents a model of open fractures with soft tissue defect, ESWT application had a significantly positive histologic effect on bone healing. However, radiological evaluation did not reveal any statistically significant difference between groups with intact and excised periosteums. Conclusion: According to our findings, ESWT can be used to improve fracture healing and prevent pseudoarthrosis in the treatment of open fractures with accompanying soft tissue and periosteum damage. However, further clinical studies are required to include ESWT in routine practice.Öğe The effect of extracorporeal shock waves on a rat model of injury to tendo Achillis - A histological and biomechanical study(British Editorial Soc Bone Joint Surgery, 2004) Orhan, Zafer; Özturan, Kutay Engin; Güven, Aysel; Çam, KamilThe effects of extracorporeal shock waves (ESWT) on tendon healing were assessed by observing histological and biomechanical parameters in a rat model of injury to the tendo Achillis. The injury was created by inserting an 18-G needle through tendo Achillis in 48 adult Wistar albino rats. The animals were divided into three groups. The first group received radiation only after the operation. The second received no shock waves and the third had 500 15 KV shocks on the second post-operative day. All the rats were killed on the 21st day after surgery. Histopathological analysis showed an increase in the number of capillaries and less formation of adhesions in the study group compared with the control group (p = 0.03). A significantly greater force was required to rupture the tendon in the study group (p = 0.028). Our findings suggest a basis for clinical trials using ESWT.Öğe Ekstrakorporeal şok dalga tedavisinin periostu sağlam olan ve periostu eksize edilmişsıçan femurlarında kırık iyileşmesine etkisi(2014) Oktaş, Birhan; Orhan, Zafer; Erbil, Barış; Değirmenci, Erdem; Üstündağ, NilAmaç: Bu çalışmada ekstrakorporeal şok dalga tedavisinin (ESWT) periostu sağlam olan ve periostu eksize edilmiş olan kırıklar üzerine etkisi karşılaştırıldı.Gereç ve yöntemler: Otuz yedi Wistar albino sıçan dört gruba randomize edildi. Ketamin anestezisi altında tüm sağ femurlara osteotomi ve intramedüller olarak Kirschnerteli tespiti uygulandı. İlk grup (n10) kontrol grubu olarak tanımlandı. İkinci grupta (n10), osteotomi hattındaki periost cerrahi sırasında çevresel olarak eksize edildi. Üçüncü grupta (n9), periost sağlam bırakılarak ESWT uygulandı. Dördüncü grupta (n8), tüm sıçanların periostları eksize edildi ve ESWT uygulandı. Tüm kırık hatları iki haftada bir radyolojik olarak ve altıncı haftada histolojik olarak değerlendirildi. Sonuçlar istatistiksel olarak değerlendirildi.Bulgular: Yumuşak doku defektli açık kırık modelini temsil eden, periostu eksize edilen grupta, ESWT uygulaması kırık iyileşmesi üzerinde anlamlı şekilde olumlu bir histolojik etkiye sahipti. Ancak radyolojik değerlendirme periostu sağlam olan ve eksize edilen gruplar arasında istatistiksel olarak anlamlı bir fark göstermedi.Sonuç: Bulgularımıza göre, yumuşak doku ve periost hasarının eşlik ettiği açık kırık tedavisinde, kırık iyileşmesini hızlandırmak ve psödoartroz oluşumunu engellemek amacıyla ESWT kullanılabilir. Ancak ESWT'nin rutin uygulamaya dahil edilebilmesi için daha fazla klinik çalışma gereklidir.Öğe Evaluation of Clinical, Radiological and Functional Outcomes of Surgically Treated Ankle Fractures(Duzce Univ, Fac Medicine, 2022) Guler, Cemal; Karaduman, Zekeriya Okan; Orhan, Safak; Turhan, Yalcin; Arican, Mehmet; Turhal, Ozan; Orhan, ZaferObjective: The ankle is an important joint in the walking function of the body. Surgical treatment is required in cases where displaced and unstable fractures and joint compatibility cannot be achieved by conservative methods. The main goal of surgical treatment is to restore the anatomical position of the talus within the ankle for a normal tibiotalar joint relationship. Methods: 73 patients who were admitted to our outpatient clinics between January 2006 and October 2015, who were diagnosed with ankle fracture and underwent surgical treatment, were retrospectively evaluated and compared with the intact ankle. Results: Of the patients who had surgery; Bimalleol fracture in 34 (46.58%), trimalleol fracture in 8 (10.96%), lateral malleolar fracture in 14 (19.18%), medial malleolar fracture in 13 (17.81%), with posterior malleolar fracture in 1 ankle dislocation (1.37%) and 1 had posterior malleolar fracture with medial malleolus fracture (1.37%). According to the Lauge Hansen classification, the most common type of SER (Supination External Rotation) fracture (14 cases) (19.18%), followed by the second most common PER (Pronation External Rotation) fracture type (14 cases) (19.18%). According to the Danis -Weber classification, Type C (21 cases) (52.50%) was the most common and Type B (14 cases) (35.00%) was the second most common. When the union time was analyzed according to the fracture type, no statistically significant difference was observed (p=0.064). Conclusions: If surgical treatment is applied in ankle fractures the length of the fibula should be ensured, rigid internal fixation should be made with the aim of anatomical reduction of the joint surface, and ankle movements should be started early.Öğe Evaluation of the Clinical Efficacy of Using Thermal Camera for Cryotherapy in Patients with Total Knee Arthroplasty: A Prospective Study(Mdpi, 2019) Karaduman, Zekeriya Okan; Turhal, Ozan; Turhan, Yalçın; Orhan, Zafer; Arıcan, Mehmet; Uslu, Mustafa; Cangür, ŞengülBackground and objectives: Cryotherapy is a method of treatment using cold application. This study aimed to evaluate postoperative clinical and hematological parameters and pain associated with total knee arthroplasty in patients and compared cryotherapy to the conventional method of cold ice pack compressions. Materials and Methods: Between January 2015 and January 2016, 90 patients who underwent total knee arthroplasty for grade 4 gonarthrosis were prospectively evaluated. The patients were divided into three groups (n = 30, each): Group 1, cryotherapy was applied in the pre- and postoperative periods; Group 2, cryotherapy was applied only in the postoperative period; and Group 3 (control group), only a cold pack (gel ice) was applied postoperatively. In all groups, pre- and postoperative evaluations at 6, 24, and 48 h, hemorrhage follow-up, knee circumference measurement, visual analog scale pain score, knee circumference, and temperature measured by thermal camera were recorded. Results: Of the 90 patients, 10% were men and 90% were women. The mean age was 64.3 +/- 8.1 (range: 46-83) years. The patella upper end diameter values were significantly lower in the postoperative period in Groups 1 and 2 than in Group 3 (p = 0.003). Hemoglobin levels at 24 and 48 h postoperatively were significantly lower in Group 3 than in Group 1 (p < 0.001, each) and Group 2 (p = 0.038, p < 0.001). At 6, 24, and 48 h follow-ups, pain values were significantly lower in Group 2 than in Group 3 (p < 0.001). Preoperative 6, 24, and 48 h temperature values were significantly lower in Group 1 than in Group 3 (p < 0.001 for each). It was found that the difference between preoperative and postoperative knee flexion measurements was significantly different in both groups or the difference between the groups was changed in each period (p < 0.001). Conclusions: Postoperative cryotherapy is a potentially simple, noninvasive option and beneficial for the reduction of reducing pain, bleeding, length of stay, analgesic requirement and swelling after total knee arthroplasty. Moreover, there was no early or late prosthesis infection in cryotherapy groups, which may be considered as an additional measure to prevent prosthesis infection.Öğe Low Back Pain Among Nurses A Review(Lippincott Williams & Wilkins, 2009) Döşoğlu, Murat; Yıldız, Umut; İş, Merih; Orhan, ZaferLow back pain (LBP) among nurses has been a well-known occupational health problem. This cross-sectional Study is designed to investigate the rate of LBP in nurses working in different departments and to evaluate the relationship between psychologic factors and LBP. The general aspects of LBP were evaluated with Oswestry Low Back Pain and Disability Questionnaire and a 10 cm Visual analog scale among 118 nurses. Psychologic state was evaluated with Beck Depression Inventory and Brier Symptom Inventory. Student t test ror independent samples and chi(2) test Were used in univariate analysis. One-way analysis of variance was used to compare the parametric variables of 3 groups of nurses. The mean number or pain attacks was significantly higher among nurses working in Emergency/Intensive Care Unit (mean: 5.4) than those ill Surgery department (mean 4.6) and in Internal Medicine Department (mean: 2.2), respectively, (P = 0.031). The mean Beck Depression Inventory score of subjects with pain (mean: 9.8) was significantly higher than those without pain (mean: 5.6, P <= 0.002). The mean Brief Symptom Inventory scores of depression, somatization, and hostility were significantly higher in Subjects with pain than in subjects without pain (P = 0.002; P = 0.000; P = 0.012, respectively). The Subjects with back pain showed statistically significant higher rates of mild mood disturbance and depression (P = 0.027). Further studies about file causes and associations of LBP among nurses are needed as the preventive measures call be undertaken.Öğe Primary subcutaneous cyst hydatic disease in proximal thigh: an unusual localisation: a case report(Biomed Central Ltd, 2003) Orhan, Zafer; Kara, Hasan; Tüzüner, Tolga; Şencan, İrfan; Alper, MuratBackground: Musculoskeletal hydatidosis is very rare and represents 1% - 5.4% of all cases of echinococcosis. On clinical basis, infection mimics a soft-tissue tumor, and the preoperative radiological diagnosis is very important to avoid biopsy. Case Presentation: We report an unusual case of primary subcutaneous hydatidosis in proximity to vastus lateralis muscle. It was diagnosed according to the computed tomography appearance, clinical and pathological findings. A 43 year old female patient was admitted with a history of pain at proximal thigh for the last 30 days. On physical examination, a mass which was 4 x 5 cm in diameter, painful and erythamatous, was palpated over greater trochanter. Sedimentation rate was 40 mm in the first hour. CT (Computed Tomography) scan demonstrated, a soft tissue mass with central cystic component in the subcutaneous tissue near vastus lateralis muscle. Histopathological examination of the specimen revealed a pericystic structure, which consisted of connective tissue and scattered hyaline cells showing a necrotic basophilic structure that resembled a cuticular membrane. Treatment with high dose albendazole was conducted for 4 weeks. Conclusions: This case illustrates that echinococcal disease should be considered in the differential diagnosis of every cystic mass in every anatomic location, especially when they occur in areas where the disease is endemic.Öğe Systemic tranexamic acid promotes bone healing in a rat model of femur fracture(Turkish Joint Diseases Foundation, 2020) Karaduman, Zekeriya Okan; Arican, Mehmet; Turhan, Yalcin; Turhal, Ozan; Orhan, Zafer; Gamsizkan, MehmetObjectives: This study aims to investigate the effect of tranexamic acid (TXA) on the union of closed femoral fractures using radiological and histological methods in an experimental rat model. Materials and methods: This experimental study was conducted between June 2017 and February 2018. Closed femoral fractures were created in 36 male Wistar albino rats (age: three months [range. 2.5-3.5 months]. weighing 200 grams [range. 180-220 grams]). Half of the animals randomly divided into two groups were administered intravenous single dose of TXA (30 mg/kg). whereas the animals in the control group did not receive any medication. The animals in the two groups were randomly divided into three groups with six animals each and cervical dislocation was performed at days 15, 30, and 45, and radiological and histopathological healing scores were compared. Results: When the mean radiological scores of the TXA and control groups were compared. a statistically significant difference was found in favor of the TXA group at day 15 (p=0.019). but no significant difference was found in the mean scores on days 30 and 45 (p=0.138 and p=0.269. respectively). Histopathological examination also showed a statistically significant difference between the 15-day mean score values in favor of the TXA group (p=0.017). Conclusion: The use of systemic TXA accelerates early bone formation and fracture healing.Öğe Topical or intravenous administration of tranexamic acid accelerates wound healing(Turkish Joint Diseases Foundation, 2024) Saglam, Sonmez; Orhan, Zafer; Arican, Mehmet; Turhan, Yalcin; Karaduman, Zekeriya Okan; Tekce, Yildiray; Yucel, Muecahid OsmanObjectives: In this study, we aimed to investigate the morphological and histological effects of tranexamic acid (TA) on wound healing in a rat wound model.Materials and methods: A total of 24 adult mal e Wistar Albino rats were used in this study. All rats were simple randomly divided into three groups including eight rats in each group. A full-thickness skin defect was created on the back of the rats in all groups. Serum physiological (2 mL) was instilled saline drops after wound formation (control group). Wound was created and topical TA (0.12 to 0.15 mL [30 mg/kg]) was applied (local group). Intravenous TA (0.12 to 0.15 mL [30 mg/kg]) was applied intravenously before the wound was created (intravenous group). The wound diameters of the groups were photographed and measured on Days 0, 3, 7, 10, 14 and, at the end of Day 14, the rats were sacrificed and their histopathological results and wound diameters were compared.Results: Fibroblast count values of the control group were found to be significantly lower than the local group (p=0.002), and no significant difference was observed between the local and intravenous groups (p>0.05). The collagen density (%) values of the control group were found to be significantly higher than the local and intravenous groups (p=0.016 and p=0.044). Wound diameter values of the control group on Day 10 day were found to be significantly higher than the local and intravenous groups (p=0.001). In addition, the wound diameter values of the control group on Day 14 were found to be significantly higher than the local and intravenous groups (p=0.001 and p=0.0001). The wound diameter changes of the control group on Days 0-10 were found to be significantly lower than the local and intravenous groups (p=0.001). In addition, the wound diameter changes of the control group on Days 0-14 were found to be lower than those of the local and intravenous groups (p=0.001 and p=0.0001).Conclusion: The use of local or intravenous TA may have positive effects on the fibroblast count and wound contraction in a rat wound model.Öğe Traumatic ganglion cyst of the peroneal muscle(2007) Orhan, Zafer; Şafak, Alp Alper; Yazıcı, Burhan; Yıldırım, Ümran; Karaduman, Zekeriya OkanWe report a rare case of ganglion cyst that occurred in peroneal muscle following a unique trauma. A 25 years old man was referred to us with a painful swelling mass on his right calf 2 months after getting a kick while playing football. Magnetic resonance imaging showed a multiseptated cyst in right peroneal muscle. The lesion was totally excised. Microscopic examination revealed cystic development without lining epithelium but with a fibrous tissue contained mild myxoid metaplasia wall surrounded by muscle fibers. There was no recurrence 6 months after the surgery. © 2007 Elsevier Ireland Ltd. All rights reserved.Öğe An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: a case report(Springer, 2009) Orhan, Zafer; Oktaş, Birhan; Yıldırım, ÜmranPigmented villonodular synovitis (PVS) is a benign proliferative disorder of unknown origin that affects synovial joints, most commonly the knee. The joint knee can be affected by localized or diffuse form. Diffuse PVS, the aggressive form of the disease is much more problematic, especially when it extends extra-articularly, and is associated with high recurrence rates. Although this disease is categorized as an inflammatory process rather than a neoplasm, it may be locally destructive and involve muscles, tendons, bone and skin. Neural involvement of the disease is rather rare, and only limited knowledge about neuropathy due to PVS we have yet. The presentation of the disease in our patient is a peroneal neuropathy which is the first reported case in English language literature of PVS of the knee seen with extra-articular tissue involvement.
