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Öğe Alterations in placental pendrin expression in pre-eclampsia(Informa Healthcare, 2014) Karataş, Ahmet; Erdem, Havva; Albayrak, Mustafa; Oktay, Murat; Özlü, Tülay; Çakmak, Bülent; Dönmez, Melahat EmineIntroduction: Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control. We aimed to investigate the relationship between pendrin immunostaining intensity in normal and pre-eclamptic placental tissue. Methods: Fifty-six placental tissues, of which 26 were in pre-eclamptic, and 30 were in control group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Results: There was more positive immunstaining in the pre-eclamptic placenta compared to the controls (p<0.001). A significant positive correlation was observed between immunostaining level and diastolic blood pressure (r = 0.533, p = 0.005) in the pre-eclamptic group. However, no significant correlation was observed between any condition and immunostaining level in the control group. Conclusions: Placentas in the pre-eclamptic group were significantly more immunostained with pendrin than were those in the control group. In addition, a positive correlation between immunostaining intensity with pendrin and both systolic and diastolic blood pressure were observed. Pendrin may play a role in the mechanism of severe hypertension in women with pre-eclampsia.Öğe Apoptozis Hakkında Bilinenler (Literatür Taraması)(2012) Eröz, Recep; Karataş, Ahmet; Alkoç, Ozan Alper; Baltacı, Davut; Oktay, Murat; Çolakoğlu, SerdarCanlı organizmalarda organogenezisten, çeşitli hastalıklara kadar birçok mekanizmada rol alan apoptozis, en çok dikkat çeken ve üzerinde çok sayıda araştırmaların yapıldığı bilinmesi gereken önemli bir mekanizmadır. Biz bu derlemede apoptozis ile ilgili bilinenleri okuyuculara sunmaya çalıştık.Öğe Are insulin resistance and serum resistin levels increased in women with idiopathic hirsutism?(Verduci Publisher, 2014) Erkan, Müşerref; Albayrak, Mustafa; Karataş, Ahmet; Keskin, Fatih; Aydın, Yusuf; Ak, H.Y.; Bıyık, İsmailOBJECTIVE: To investigate the insulin resistance and serum resistin levels in women with idiopathic hirsutism compared to controls and women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: Three groups of women including 23 women with idiopathic hirsutism, 28 women with PCOS and 28 non-hirsute women serving as controls were included into the study. The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), serum fasting insulin and resistin levels were compared between the groups. RESULTS: There were no statistically significant differences regarding the age, BMI and waist circumferences between the groups. Mean and median fasting blood glucose, fasting insulin, HOMA-IR, serum resistin levels were statistically similar between the groups (p = 0.966, p = 0.378, p = 0.409 and p = 0.784, respectively). There were no correlations between the resistin, HOMA-IR, fasting insulin levels and BMI in any of the three groups. CONCLUSIONS: Insulin resistance and serum resistin levels do not appear to be increased in women with idiopathic hirsutism compared to controls at similar BMI's and waist circumferences.Öğe Association of Between Heavy Metal and Trace Element Levels in Blood and Cervical Mucus with Female Infertility(Ortadogu Ad Pres & Publ Co, 2012) Ilgın, Halil; Hassa, Hikmet; Karataş, Ahmet; Kahraman, Salih; Ilgın, BadeObjective: Infertility affects 10-15% of couples during the reproductive period. Ovulatory disorders are more common in younger women whereas unexplained infertility occurs more commonly in older women. Recently, many environmental agents, such as cigarettes, alcohol, heat, electromagnetic energy and radiation have been shown to have negative effects on the reproductive system. Environmental factors and exposure to heavy metals change fertility patterns in adults by affecting germ cell maturation, fertilization and the endocrine system. We aimed to investigate the effect of trace elements and heavy metals in blood and cervical mucus on female infertility. Material and Methods: Study was performed with 50 women: Infertile (n=35) and controls (n=15). Blood and cervical mucus samples were collected to measure Zn, Cu, Cd, and Pb levels. Results: Mean blood plasma and cervical mucus Zn, Cd, and Cu levels in the infertile group were significantly lower than those in the control group. Whole blood Pb level was higher in the infertile group compared to the control group. Although blood Cd level tended to be higher in smokers and cervical mucus Cd level tended to be lower in controls, neither of these difference were statistically significant. Condusion: Lower levels of plasma and cervical mucus Zn and Cu were thought to result from higher levels of Cd and Pb in blood and cervical mucus. Abnormal levels of heavy metals in blood and cervical mucus may have adverse effects on the female reproductive function.Öğe Branch Retinal Vein Occlusion Associated with Tamoxifen Use(Informa Healthcare, 2013) Önder, Halil İbrahim; Kılıç, Ali Çağrı; Köse, Seyit Ali; Karataş, Ahmet; Kaya, Ertuğrul; Kaya, Murat; Tunç, MuratTamoxifen is a selective estrogen receptor modulator widely used in the treatment of hormone-responsive breast cancer. Tamoxifen-induced ocular complications are very rare. A post-menopausal woman with carcinoma of the left breast had presented with sudden loss of vision. The patient had been on tamoxifen therapy 20 mg daily for the last three years. Fundus examination showed left branch retinal vein occlusion. Fluorescein angiography and optical coherence tomography confirmed the diagnosis. Tamoxifen therapy was discontinued. Although branch retinal vein occlusion is rare, careful evaluation of patients on tamoxifen therapy with visual symptoms is required.Öğe Comparison of Ectopic Pregnancy Treatment Modalities: Experience from a Tertiary Center(Kuwait Medical Assoc, 2013) Albayrak, Mustafa; Karataş, Ahmet; Bıyık, İsmail; Keskin, FatihObjectives: To review and analyze the outcomes of various treatment modalities in women with ectopic pregnancy (EP) in a tertiary center between January 2006 and February 2011 Design: Retrospective study Setting: Duzce University Hospital, Turkey Subjects and Methods: The medical records of 116 women diagnosed with EP were reviewed retrospectively. Women were grouped based on the treatment modality: Expectant (Group I), Medical treatment with methotrexate (Group II) and Surgical (salpingostomy and salpingectomy) (Group III). Demographic characteristics were analyzed and the success rates between the groups were compared. Intervention: None Main Outcome Measures: Success rates between groups based on treatment modality Results: Success rates for expectant, medical management with single dose of methotrexate, salpingostomy and salpingectomy were 66.7%, 79%, 92.7% and 100%, respectively. There was no difference between the success rates of laparoscopic salpingostomy and single dose methotrexate (p = 0.246). Salpingectomy was more successful compared to expectant and medical managements (p = 0.003 and p = 0.040, respectively). Conclusion: The highest success rate in EP was achieved by surgical treatment. However, expectant and medical treatment may eliminate the need for surgery in selected cases with low and / or decreasing initial beta-hCG levels.Öğe The Effect of Blood and Seminal Plasma Heavy Metal and Trace Element Levels on Sperm Quality(Ortadogu Ad Pres & Publ Co, 2012) Kahraman, Salih; Hassa, Hikmet; Karataş, Ahmet; Ilgın, HalilObjective: Infertility is shown in approximately 10-15% of the couples. Male infertility is responsible for at least 50% of them. In these infertile couples, male is responsible alone in 30% while male and female are responsible together in 20%. The semen analysis is the first laboratory test which should be done to evaluate the male infertility. Heavy metals and trace elements affect sperm production, motility and morphology. The aim of this study is to determine zinc, copper, lead and cadmium levels in blood and seminal samples of men and to evaluate their relationship with sperm quality parameters. Material and Methods: Forty-two men with abnormal sperm quality parameters and 10 control subjects were included in the study. Zinc, copper, cadmium and lead levels were measured in blood and semen. The results were compared. Results: Lead levels in blood, cadmium levels both in blood and seminal plasma were significantly higher in men with abnormal sperm analyses (p<0.05). There was a positive correlation between seminal plasma zinc level and sperm count, motility and morphology (p<0.001) and between seminal plasma copper level and sperm count and morphology (p<0.05). There was a negative correlation between lead level and sperm count, motility and morphology (p<0.001). Likewise, there was a negative correlation between blood cadmium level and sperm motility and morphology (p<0.05) and between seminal plasma cadmium level and sperm motility (p<0.05). Conclusion: Zinc and copper affect sperm quality positively whereas lead and cadmium shows a negative effect. Exposure to heavy metals is an important etiology in the male infertility problem and should be treated seriously.Öğe The effect of plasma ghrelin and serum leptin levels on growth in breastfed and formula-fed infants during early infancy period [Erken bebeklik döneminde anne sütü ve formül mama ile beslenen bebeklerin ghrelin ve leptin düzeylerinin büyüme üzerine etkisi](2011) Karataş, Zehra; Aydoğdu, Sultan Durmuş; Karataş, Ahmet; Aydın, BanuObjective: To evaluate the effects of ghrelin, leptin and lipid levels on growth status of healthy infants fed with breastmilk (BF) and formula (FF). Material and Metods: This study was performed in 46 healthy infants. The study group was subdivided into two subgroups according to nutrition status as breastfed and formula infants. These infants were evaluated at two different times (mean of the second and fifth months, respectively). The ghrelin, leptin, triglyceride and total cholesterol levels of infants were studied at the first visit. Results: Plasma total ghrelin concentrations were significantly higher in BF group than FF group(p<0.05). Although the serum leptin level was not statisticaly significant, it was higher in BF group. In BF group, positive correlations were found between total ghrelin concentrations and mid-arm circumference and triceps skinfold thickness (TST) at first visit. Serum leptin levels were positively correlated to BMI at both visits (p<0.05) and TST at second visit (p<0.01). In the FF group, positive correlations were found between total ghrelin levels and head circumferences at first visit and body weight at second visit (p<0.05). One breastfeeding period was longer, feeding frequency and defecation frequency were higher in BF group than FM group (p<0.01, p<0.01, p<0.05; respectively). Conclusion: High ghrelin and leptin levels in BF group suggests that these hormones pass to the baby with breast milk, high ghrelin levels are effective on a more rapid weight gain in the first few months and have long term effects on energy metabolism. The lower ghrelin and leptin may be associated with contents of FF or type of bottle feeding in FF group. © 2011 Düzce Medical Journal.Öğe The effect of smoking on placental pendrin expression(Taylor & Francis Inc, 2017) Karataş, Ahmet; Erdem, Havva; Karataş, Zehra; Özlü, Tülay; Çakmak, BülentPendrin is important for transport of iodine across the placenta. Thiocyanate coming from cigarette is a competitive inhibitor of iodine transport. We aimed to evaluate the pendrin immunostaining intensity in placentas of smoker and non-smoker women. Placental tissues from 61 women, of which 28 were in smoking, and 33 were in non-smoking group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Birth weight was significantly lower in the smoker group (p=0.024). There was a negative correlation between birth weight and intensity of placental pendrin immunostaining in the smoker group (r=-0.44, p=0.02). Placentas of the smoking women showed significantly higher immunostaining with pendrin than the control group (p=0.006). Thiocyonate coming from cigarettes may competitively inhibit pendrin mediated iodine transport in the placenta and adversely affect foetal development by this mechanism.Öğe Endothelial Nitric Oxide Synthase Gene Polymorphisms (Promoter-786T/C, Exon 894 G/T and Intron G10T) in Unexplained Female Infertility(Karger, 2014) Karataş, Ahmet; Eröz, Recep; Bahadır, Anzel; Keskin, Fatih; Özlü, Tülay; Özyalvaçlı, Mehmet EminBackground/Aims: Recent investigations in both males and females show that there may also be some genetic risk factors associated with infertility, and endothelial nitric oxide synthase (eNOS) has important functions in implantation. We aimed to investigate the association of three different polymorphisms of eNOS (promoter -786T/C, exon 894 G/T and intron G10T) with unexplained female infertility. Materials and Methods: Two groups of patients were included in the study: (1) women with unexplained infertility and (2) healthy, fertile women with normal menstrual cycles. eNOS polymorphisms were studied in genomic DNA of each patient by polynnerase chain reaction-restriction fragment length polymorphism method. Results: Forty-one women with unexplained infertility and 40 fertile women were included. Baseline physical characteristics and hormonal parameters of the two groups were similar. For eNOS exon 894 G/T polymorphism, the GG honnozygotes were significantly lower and the heterozygotes GT were significantly higher in the infertile group than in the control group (p < 0.05). eNOS gene polymorphism both for promoter and intron were similar in the two groups (p > 0.05). Conclusion: Altered eNOS protein caused by eNOS exon 894 G/T polymorphism might cause implantation failure, which may be a possible cause of unexplained female infertility. (C) 2014 S. Karger AG, BaselÖğe The evaluation of carotid intima-media thickness and visceral obesity as an atherosclerosis predictor in newly-diagnosed polycystic ovary syndrome(Societa Editrice Universo, 2014) Büyükkaya, Ramazan; Beşir, Fahri Halit; Yazgan, Sibel; Karataş, Ahmet; Köse, S.A.; Aydın, Y.; Erdoğmuş, B.Purpose. Polycystic ovary syndrome (PCOS) is a common endocrine disorder which is associated with multiple risk factors for atherosclerosis. The aim of this study was to investigate the CIMT which is used in the early diagnosis of atherosclerosis and visceral obesity by ultrasound in newly diagnosed polycystic ovary syndrome with normal body mass index. Materials and Methods. A case-control study was conducted on 25 PCOS women (18-30 years of age) and 25 controls. BMI was matched volunteer controls. Carotid intima media thickness (CIMT) and fat distribution as visceral fat thickness (VFT) with subcutaneous fat thickness (SFT) were measured by ultrasound. After, visceral fat ratio (VFR) fat ratio (VFR) was calculated using VFT divided by SFT. The variables were compared using the ?2-test and Student's t test. Results. Comparing women with PCOS to the control group showed that CIMT was similar in both groups (p=0.84). The VFT in the PCOS group was higher than the control group (p=0.048). Whereas, the SFT was higher in the control group when compared to women with PCOS (p=0.007). The VFR was significantly higher in women with PCOS when compared to the control group (1.12 ± 0.38 vs. 0.81 ± 0.34; p=0.005). Conclusions. CIMT which used as early atherosclerosis predictors have not increased in newly diagnosed PCOS women. Body fat distribution was observed in visceral area in the newly diagnosed PCOS women. VFR follow up may provide benefit as a quantitative method for the assessment and follow up of visceral obesity in women with PCOS. © Società Editrice Universo (SEU).Öğe Evaluation of chromosomal abnormalities and common trombophilic mutations in cases with recurrent miscarriage(Makerere Univ, Fac Med, 2014) Karataş, Ahmet; Eröz, Recep; Albayrak, Mustafa; Özlü, Tülay; Çakmak, Bülent; Keskin, FatihBackground: Recurrent miscarriage (RM) is a frequent obstetric problem. Its' pathophysiology is poorly understood. Infections, genetic, endocrine, anatomic and immunologic problems have been suggested as causes for RM. Objective: To evaluate the frequency of chromosomal abnormalities and 3 common thrombophilic mutations in couples with RM. Methods: A retrospective data collection was performed for the results of the cytogenetic analysis of the couples and Methylenetetrahydrofolate Reductase (MTHFR) C677T, Factor V Leiden (FVL) G1691A and Prothrombin (PTm) G20210A mutations of the mother in 142 couples suffering from RM. Results: Prevalence of FVL, MTHFR, and PTm gene mutations were similar between cases shaving 2 or >= 3 abortions (P=0.528; P=0.233; P=0.375). In patients with FVL, MTHFR and PTm gene mutations, the OR's of having >= 3 abortions when compared to having 2 abortions were 1.515 (95% CI: 0.414-5.552), 0.573 (95% CI: 0.228-1.441), and 2.848 (95% CI: 0.355-22.871). All cases with PTm mutation had >= 3 abortions and all abortions occurred between 6-8 gestational weeks. Conclusion: Chromosomal abnormalities and thrombophilic mutations (especially PTm) seem to have an important role in RM. Additional larger studies involving investigation of more genes that may have a role in pregnancy are needed to assess this association.Öğe Evaluation Of Direct Antiglobulin Test Positivity In Neonates(Düzce Üniversitesi, 2011) Karataş, Ahmet; Akşit, Mehmet Arif; Tekin, Neslihan; Karataş, ZehraAim: The objective of the present study is to determine clinical, laboratory findings, treatmentand prognosis in newborns with positive direct antiglobulin test (DAT).Methods: Ninety-seven patients with positive direct coomb’s test from 2362 newborns whowere hospitalized in Neonatology Unit of Eskisehir Osmangazi University Faculty of Medicinebetween June 2004-November 2006 were reviewed retrospectively. Chi-square test was usedfor statistical analysis.Results: The prevalance of DAT was 4.1%. Twenty-six patients were premature. In 75 patientsDAT was positive initially. The initial DATs were negative in 34.6% of prematures and 14% ofterm newborns. But later, the DATs of all these babies were positive, when they were beingfollowed up in hospital. Hemolysis was determined in 41 patients. There were blood groupincompatibilities (ABO:44, Rh:12, ABO and Rh:6) in 62 patients. 67 patients were underwentphototherapy and 52 patients were treated with intravenous immunoglobulin (IVIG). Exchangetransfusion was performed in 15 patients. Eventually; neonatal cholestasis devoloped in sixpatients and ten patients died.Conclusion: The most common etiologic factor in the newborns with positive DAT is bloodgroup incompatibility. IVIG therapy reduces the need for exchange especially in the earlydiagnosis of ABO hemolytic disease. Prematurity and accompanying systemic inflammatoryresponse syndrome (SIRS) and/or infections may be the causes of positive DAT without immunehemolytic anemiaÖğe Evaluation of Knowledge and Attitude of Eskisehir Osmangazi University Medical and Agricultural Faculty’s Students on Sexually Transmitted Diseases and Family Planning(Düzce Üniversitesi, 2012) Özalp, Sinan; Tanır, Hüseyin Mete; Ilgın, Halil; Ilgın, Bade; Karataş, AhmetPurpose: The aim of this study was to evaluate attitude and level of knowledge of the studentsfrom faculty of medicine and engineering about sexually transmitted diseases (STDs) and familyplanning(FP).Methods: A total number of 208 students (72 medical faculty and 136 from faculty ofengineering) were included into the study. A questionnaire, composed of 18 questions regardingSTDs and FP was conducted.Results: Most of the students (98.6%) were aware of HIV/AIDS. The least known STD wasgonorrhea (12.5%). Medical students were more aware of gonorrhea, compared to other group(22.2%vs7.4%, pÖğe Geç Preterm Doğum Olgularında Erken Neonatal Sonuçlar(2013) Karataş, Ahmet; Albayrak, Mustafa; Keskin, Fatih; Bıyık, İsmail; Okur, Mesut; Güneş, Cemalettin; Köse, Seyit AliAmaç: Preterm doğumlar son zamanlarda birçok ülkede artış göstermiştir. Fetal akciğerin gelişmiş olmasına rağmen, 34. gebelik haftasından sonra bile ciddi yenidoğan morbiditesi meydana gelebilir. Bu çalışmanın amacı, geç preterm doğum olgularında neonatal morbidite ve mortaliteyi araştırmaktır. Planlama: Retrospektif Ortam: Düzce Üniversitesi Tıp Fakültesi, Kadın Hastalıkları-Doğum ve Pediatri Kliniği Hastalar: 340/7-366/7 gebelik haftasında doğum yapan 291 gebe kadın ve yenidoğanlar incelendi. Girişim: Çalışmaya dahil edilen olgular PPROM varlığı ya da yokluğuna göre öncelikle iki gruba ayrıldı. Daha sonra gruplar, tekrar gebelik haftasına göre kendi içlerinde, 340/7-346/7 hafta olanlar(grup 1),350/7-356/7 hafta olanlar (grup 2), 360/7-366/7 hafta olanlar(grup 3) şeklinde üçe ayrıldı. Değerlendirme parametreleri: Gruplar prematürite ve erken membran rüptürü ile ilişkili yenidoğan komplikasyonları açısından karşılaştırıldı. Sonuç: Çalışmaya dahil edilen ikiyüz doksanbir olgunun 85'i PPROM nedeniyle erken doğum yapmıştı. 206'sı PPROM olmayan gruptaydı ve 76'sı 1. grup, 108'i 2. grup, 107'si de 3. grupta yer aldı. Sepsis oranı, birinci ve ikinci grupta üçüncü gruba göre daha yüksekti (p:0.016, p:0.029). Yenidoğan yoğunbakım ünitesinde (YDYB) kalış süresi 3. gruba oranla, 1. ve 2. grupta daha yüksekti (sırasıyla p:0.028, p:0.015). Birinci gruptaki yenidoğanlar, üçüncü gruptakilere göre anlamlı olarak daha uzun hastanede kalış süresine sahipti (p0.010), ve toplam hastanede kalış süresi sepsisli yenidoğanlarda anlamlı olarak daha yüksekti. Yorum: Özellikle daha erken gebelik haftalarında olan geç preterm yenidoğanlar, yenidoğan komplikasyonları için anlamlı olarak daha fazla risklidirler, aynı zamanda anlamlı olarak yenidoğan yoğun bakım ve hastanede daha uzun kalış süresine sahiptir.Öğe Ghrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarum(Taylor & Francis Ltd, 2013) Albayrak, Mustafa; Karataş, Ahmet; Demiraran, Yavuz; Erman, Hayriye; Topuz, Seren; Bıyık, İsmail; Erkan, MüşerrefObjective: To assess the serum levels of gut and adipocyte-derived metabolic hormones that control appetite, adipocity, weight gain and energy hemostasis, namely total ghrelin (TG), acylated ghrelin (AG), leptin and PYY-3 in hyperemesis gravidarum (HG). Methods: Plasma samples of 86 women in their first trimester pregnancies with HG (n = 30), morning sickness of pregnancy (MSP) (n = 34) and control (n = 22) groups were obtained. Serum levels of TG, AG, leptin and PYY-3 were compared between the groups, and the correlations with severity of symptoms using modified PUQE (Pregnancy Unique Quantification of Emesis) scoring, BMI, E2, hCG and TSH were calculated. Results: Levels of TG, AG, PYY-3 and the TG/leptin ratio were significantly higher in HG group compared to MSP and the control groups (p <= 0.017). AG/TG ratio was significantly lower in the HG group compared to both MSP and control groups (p <= 0.017). There were either weak or no significant statistical correlations between the gut and adipose-related hormones and the modified PUQE scores, BMI, E2, hCG and TSH. Conclusion: Gut-derived metabolic hormones ghrelin, AG and PYY-3 may be involved in the HG pathophysiology.Öğe Hysteroscopic Operations: Six Year Experience(Düzce Üniversitesi, 2013) Bıyık, İsmail; Köse, Seyit Ali; Albayrak, Mustafa; Keskin, Fatih; Karataş, AhmetObjective: The hysteroscopy provides seeing of endoservix and uterin cavity with a camera andtreatment of pathologies by this way. It can be used as diagnostically and operatively. We decidedto present the hysteroscopic operations and findings performed for diagnostic and operativereason in gynecology clinic at last six year.Material and Methods: The hysteroscopic operations which performed between January 2006 December 2011 were retrospectively evaluated. A totaly 166 cases in which the hysteroscopywas done for diagnostic and operative purpose were included into study. The prostoglandin E1analogue (misoprostol 200 mcg 1 tablet ) was used for cervical priming vaginaly beforeoperation night in all cases.Results: The mean age, gravida, parity and living child numbers of cases were 43 ± 11 years,2.4 ± 1.4, 2.6 ± 1.5 and 2.3 ± 1.6, respectively. The diagnostic hysteroscopy carried out in 12cases for infertiliy, and while operative hysteroscopy was performing in 59 cases for endometrialand endocervical polips, it was used for abnormal uterin bleeding and uterin leiomyomasindication in 35 and 24 cases respectively. While the endometrial hyperplasia was detected ineight cases, the endometrial adenocarsinom was detected in three cases. The uterin perforationdeveloped in five (3%) cases during operation.Conclusions: The hysteroscopy should be used more effectively in abnormal uterin bleedingand especially in postmenopausal bleedings. To prevent uterin perforation, the bimanualexamination of cases under anesthesia before presedure will be usefulÖğe İpi Görünmeyen Ria Gebeliğin İlk Üç Ayında Çıkarılmalı Mı? Olgu Sunumu(Maltepe University, 2012) Bıyık, İsmail; Akın, Ayşe; Altun, Oktay; Karataş, Ahmet[Abstract Not Available]Öğe Leopard Syndrome Presented With Hemolytic Anemia, Total Genital Prolapse And Ovarian Agenesis(2012) Kutlucan, Ali; Köse, Seyit Ali; Karataş, Ahmet; Aydın, Leyla Yılmaz; Coşkun, Hülya; Erkan, Müşerref; Turan, HakanLeopard sendromu, multipl lentigolar, elektrokardiyografik iletim kusurları, gözde hipertelorizm, pulmoner stenoz, genital anormallikler, büyüme geriliği ve sensorinöral sağırlıkla seyreden otozomal dominant geçiş gösteren nadir, multisistemik bir hastalıktır. Çoğu vaka çocukluk ve ergenlik döneminde bildirilmiş olup, genellikle kalp anormallikleri ve lentigolar şeklinde sunulmuştur. Bizim vakamız ise kardiyak anomaliye bağlı portal hipertansiyon gelişmesi sonucu ileri yaşta tanı almıştır. Ayrıca yatışı sırasında, portal hipertansiyonun neden olduğu diffüz asit, masif splenomegalinin neden olduğu hemolitik anemi saptanmıştır. Olguda genital operasyon öyküsü olmamasına rağmen, ovaryen agenezi ve genital prolapsus tesbit edilmiştir. İleri yaşta tanısı konulan, pulmoner stenoz komplikasyonları gelişmiş olup ovaryen agenezi olan böyle bir vaka, literatürde daha önceden bildirilmemiştir.Öğe Leopard syndrome presented with hemolytic anemia, total genital prolapse and ovarian agenesis(2012) Kutlucan, Ali; Köse, Seyit Ali; Karataş, Ahmet; Aydın, Leyla Yılmaz; Coşkun, Hülya; Erkan, Müşerref; Turan, HakanThe LEOPARD syndrome is a rare autosomal dominant, multisystemic disease characterised by multiple lentigines, electrocardiographic conduction defects, ocular hypertelorism, pulmonary stenosis, abnormalities of genitalia, retardation of growth and sensorineural deafness. Most of the cases were reported during their childhood or young adulthood and they usually presented with cardiac anomalies and lentigines. In our case, portal hypertension depending on cardiac anomaly developed at the time of hospital admission because of the late diagnosis of leopard syndrome. Also diffuse ascites caused by portal hypertension and hemolytic anemia caused by massive splenomegaly developed at the time of diagnosis. There was not a genital operation history but ovarian agenesis and genital prolapse were detected. As the diagnosis was established at advanced age, this case was presented with the pulmonary stenosis complications and ovarian agenesis which were not reported before in literature. © 2012 Düzce Medical Journal.
