Chemical Compositions and Antimutagenic Effects of Ethanolic Extracts of Stachys Thirkei and Stachys Annua subsp. Annua Using the Ames Assay

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dc.contributor.authorRasgele, Pinar Goc
dc.contributor.authorDulger, Gorkem
dc.date.accessioned2021-12-01T18:46:57Z
dc.date.available2021-12-01T18:46:57Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractIn this study, antimutagenic effects of ethanolic extracts of Stachys thirkei and Stachys annua subsp. annua belonging to Lamiaceae family that grow in Duzce of Turkey were investigated on Salmonella typhimurium TA98 and TA100 strains without metabolic activation using Salmonella/microsome test system. Three different concentrations (0.025, 0.05 and 0.1 mg/plate) of the ethanolic extracts of S. thirkei and S. annua subsp. were used as active materials in which the major components were 2-ethylhexanol (30.012%) and 2-beta-pinene (26.40%), respectively. The highest concentration (0.1 mg/plate) of S. thirkei had a moderate antimutagenic effect on the Salmonella typhimurium TA98 strain with a 26.79% inhibition rate. It was also established that the extract of S. thirkei at highest concentration (0.1 mg/plate) exhibited strong antimutagenic effect (with 44.03% maximum inhibition) on TA100 strain. Furthermore, it was found that 0.05 mg/plate ethanolic extract showed moderate antimutagenic activity with 25.55% inhibition rate. The highest concentration (0.1 mg/plate) of ethanolic extract of S. annua subsp. showed moderate antimutagenic activity on both Salmonella typhimurium TA98 and TA100 strains with inhibition rates of 20.39 and 22.13%, respectively. No antimutagenic activity on Salmonella typhimurium TA98 and TA100 strains was observed at the lowest doses of both plant species. As a result, it is concluded that S. thirkei and annua subsp. have antimutagenic activity and further studies may be recommended in terms of different parameters.en_US
dc.description.sponsorshipDuzce University Scientific Research FundDuzce University [2019.11.01.908]en_US
dc.description.sponsorshipThis study was supported by Duzce University Scientific Research Fund (Project Number, 2019.11.01.908).en_US
dc.identifier.doi10.1007/s11094-021-02351-x
dc.identifier.endpage1262en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85102246884en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1255en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-021-02351-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10073
dc.identifier.volume54en_US
dc.identifier.wosWOS:000626351900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStachys thirkeien_US
dc.subjectStachys annua subspen_US
dc.subjectannuaen_US
dc.subjectantimutagenicityen_US
dc.subjectAmes assayen_US
dc.titleChemical Compositions and Antimutagenic Effects of Ethanolic Extracts of Stachys Thirkei and Stachys Annua subsp. Annua Using the Ames Assayen_US
dc.typeArticleen_US

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