The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats

Basit Öğe Kaydı
dc.contributor.authorYön, Burcu
dc.contributor.authorBelviranlı, Muaz
dc.contributor.authorOkudan, Nilsel
dc.date.accessioned2020-04-30T13:33:35Z
dc.date.available2020-04-30T13:33:35Z
dc.date.issued2019
dc.departmentDÜ, Sağlık Hizmetleri Meslek Yüksekokuluen_US
dc.descriptionPubMed ID: 31017870en_US
dc.description.abstractThe objective of this investigation was to examine the impact of silymarin supplementation on locomotion, anxiety-related behavior, learning, and memory via several behavioral tests, such as open field, elevated plus maze, and Morris water maze tests in streptozotocin-induced diabetic rats. The rats were divided into the control, diabetes, silymarin, and diabetes plus silymarin groups. On the 30th-35th days of the study, several behavioral tests were performed and blood and brain tissue samples were taken and brain-derived neurotrophic factor (BDNF) and histone deacetylase 3 (HDAC3) levels were analyzed. There was no significant difference in locomotor activity between the groups (p = 0.534). Spatial memory was lower (p = 0.000) but anxiety scores were higher (p = 0.005) in the diabetes group than in the control, silymarin, and diabetes plus silymarin groups. Plasma (p = 0.000) and brain tissue (p = 0.007) BDNF levels were lower in the diabetes group than in the control, silymarin, and diabetes plus silymarin groups; however, plasma (p = 0.432) and brain tissue (p = 0.321) HDAC3 levels did not significantly differ between the groups. The findings obtained from this study suggest that silymarin supplementation could improve anxiety-related behavior, and learning and memory in diabetic rats by increasing the BDNF levels. © 2019 Walter de Gruyter GmbH, Berlin/Boston.en_US
dc.description.sponsorshipSelçuk Üniversitesi: 14202028en_US
dc.description.sponsorshipThis work was supported by Selçuk University Scientific Research and Project Coordinatorship (project number: 14202028).en_US
dc.identifier.doi10.1515/jbcpp-2018-0109en_US
dc.identifier.issn0792-6855
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1515/jbcpp-2018-0109
dc.identifier.urihttps://hdl.handle.net/20.500.12684/680
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDe Gruyteren_US
dc.relation.ispartofJournal of Basic and Clinical Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBDNF; cognitive function; diabetes; HDAC3; learning; silymarinen_US
dc.titleThe effect of silymarin supplementation on cognitive impairment induced by diabetes in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
0680.pdf
Boyut:
408.45 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu