Before the Needle: The Impact of Ejaculation on Prostate Biopsy Outcomes in a Prospective Comparative Study

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dc.authoridTaskiran, Arda Taskin/0000-0003-4556-3475
dc.authoridBaba, Dursun/0000-0002-4779-6777
dc.contributor.authorBaba, Dursun
dc.contributor.authorDilek, Ismail Eyup
dc.contributor.authorEkici, Necati
dc.contributor.authorOzel, Mehmet Ali
dc.contributor.authorBalik, Ahmet Yildirim
dc.contributor.authorBasaran, Ekrem
dc.contributor.authorTaskiran, Arda Taskin
dc.date.accessioned2025-10-11T20:48:37Z
dc.date.available2025-10-11T20:48:37Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackgroundAlthough transrectal ultrasound (TRUS)-guided prostate biopsy is widely used for prostate cancer diagnosis, the role of pre-biopsy ejaculation in influencing procedural outcomes and complication risk remains largely unexplored. This study aimed to evaluate whether recent ejaculation affects seminal vesicle volume, biopsy-related complications, and patient-reported outcomes.MethodsIn this prospective comparative study, 32 patients undergoing TRUS-guided 12-core prostate biopsy were divided into two groups based on their sexual activity: the ejaculation group (n = 14), who ejaculated within 24 h prior to the procedure, and the abstinence group (n = 18), who reported abstinence for at least 3 days. Data collected included seminal vesicle volume, pain scores, urinary symptoms, erectile function, quality of life, and post-procedural complications. Histopathological results were also recorded and summarized. ROC analyses were used to determine cutoff values for key complications. Although transperineal biopsy is now recommended by current EAU guidelines, our study was conducted using the transrectal approach, which remains widely practiced and relevant in clinical settings.ResultsWhile seminal vesicle volume tended to be higher in the abstinence group, the difference was not statistically significant (p = 0.184). No meaningful differences were found in pain perception, urinary symptoms, erectile function, or quality of life. However, hematospermia (p = 0.017) and hematochezia (p = 0.011) were significantly more frequent in the ejaculation group. ROC analysis showed that abstinence <= 7.5 days predicted hematospermia (AUC = 0.731), and abstinence <= 2 days predicted hematochezia (AUC = 0.760). A pain score >= 1.5 was predictive of hematuria (AUC = 0.810). Histological analysis revealed benign findings in the majority of patients, with no significant difference in cancer grade between groups.ConclusionEjaculation prior to TRUS-guided prostate biopsy may increase the risk of certain complications without negatively affecting patient comfort. Abstinence duration could serve as a simple and modifiable factor in optimizing biopsy preparation. Despite the limited sample size, this prospective study provides preliminary evidence supporting patient counseling on sexual activity prior to biopsy.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK)en_US
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK). The authors received no financial support for the research and/or author-ship of this article.en_US
dc.identifier.doi10.1007/s44411-025-00256-9
dc.identifier.endpage2794en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-105009943758en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2787en_US
dc.identifier.urihttps://doi.org/10.1007/s44411-025-00256-9
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22023
dc.identifier.volume126en_US
dc.identifier.wosWOS:001523872800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectBiopsy complicationsen_US
dc.subjectEjaculationen_US
dc.subjectProstate biopsyen_US
dc.subjectSeminal vesicleen_US
dc.subjectTransrectal ultrasounden_US
dc.titleBefore the Needle: The Impact of Ejaculation on Prostate Biopsy Outcomes in a Prospective Comparative Studyen_US
dc.typeArticleen_US

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