Effect of Resveratrol and Curcumin on Changes in Fatty Acid Composition and Oxidative Stress in Liver and Kidney Tissues of Rats Exposed to 7,12-Dimethylbenz[a]anthracene (DMBA)

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dc.authoridDemir, Ersin/0000-0002-7676-5953en_US
dc.authoridErdem Erisir, Figen/0000-0002-0499-9339en_US
dc.authoridBulut Siltar, Yesim/0000-0002-8745-6902en_US
dc.authorscopusid59155522400en_US
dc.authorscopusid56287032300en_US
dc.authorscopusid58304447100en_US
dc.authorscopusid59155807600en_US
dc.authorscopusid58974888800en_US
dc.authorscopusid57219233353en_US
dc.authorwosidDemir, Ersin/AEN-8914-2022en_US
dc.authorwosidErdem Erisir, Figen/AAB-9469-2021en_US
dc.contributor.authorSiltar, Yesim Bulut
dc.contributor.authorDemir, Ersin
dc.contributor.authorErisir, Figen Erdem
dc.contributor.authorErdogdu, Ayse
dc.contributor.authorTemizer, Ibrahim Akin
dc.contributor.authorYilmaz, Okkes
dc.date.accessioned2024-08-23T16:04:14Z
dc.date.available2024-08-23T16:04:14Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThis study was conducted for the main purpose of evaluating the effect of resveratrol and curcumin on changes in fatty acid composition in liver and kidney tissues of rats exposed to DMBA. Resveratrol groups: 40 mg/kg resveratrol was administered for only 3 days per week throughout the experiment. Curcumin groups: 40 mg/kg curcumin was administered for only 3 days per week throughout the experiment. DMBA groups: A single dose of 20 mg/kg DMBA was administered once throughout the duration of the experiment. Fatty acid composition, fat-soluble vitamins, cholesterol and phytosterol analyses analyses were performed in tissues. Antioxidant tests were also performed. It was found that the amounts of C16:0, C17:0, C17:1 and C22:5 n3 decreased significantly in the liver tissue of rats administered DMBA, but the amounts of C20:3 n6 ve C22:6 n3 increased significantly. It was found that C16:0 and C18:2 n6c levels increased significantly in kidney tissue, but C17:1 level decreased significantly. As a result of the administration of Curcumin, Resveratrol, DMBA + Curcumin and DMBA + Resveratrol in both liver and kidney tissue, it was determined that some fatty acid values decreased significantly and some fatty acid values increased significantly. Compared to the DMBA group, it was determined that all groups studied had significant changes in the amount of some fat-soluble vitamins, cholesterol, sitosterols in tissues. In conclusion the administration of DMBA, resveratrol and curcumin both single and in combination, it was found that there may be significant changes in the fatty acid composition, fat-soluble vitamins, cholesterol and phytosterols in tissue.en_US
dc.description.sponsorshipFirat University Research Projects Unit (FUBAP) [FF.17.24]en_US
dc.description.sponsorshipThis study was supported by Firat University Research Projects Unit (FUBAP) (Project no. FF.17.24).en_US
dc.identifier.doi10.1134/S1062359023606420
dc.identifier.endpage941en_US
dc.identifier.issn1062-3590
dc.identifier.issn1608-3059
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85195139230en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage932en_US
dc.identifier.urihttps://doi.org/10.1134/S1062359023606420
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14116
dc.identifier.volume51en_US
dc.identifier.wosWOS:001236820200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofBiology Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDMBAen_US
dc.subjectresveratrolen_US
dc.subjectcurcuminen_US
dc.subjectfatty acid compositionen_US
dc.subjectcholesterolen_US
dc.subjectoxidative stressen_US
dc.subjectPolycyclic Aromatic-Hydrocarbonsen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectMammary Carcinogenesisen_US
dc.subjectShemamruthaaen_US
dc.subjectCholesterolen_US
dc.subjectSuppressionen_US
dc.subjectLipogenesisen_US
dc.subjectMetabolismen_US
dc.subjectCarcinomaen_US
dc.subjectRetinolen_US
dc.titleEffect of Resveratrol and Curcumin on Changes in Fatty Acid Composition and Oxidative Stress in Liver and Kidney Tissues of Rats Exposed to 7,12-Dimethylbenz[a]anthracene (DMBA)en_US
dc.typeArticleen_US

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