Stevens-johnson syndrome caused by combined use of lamotrigine and fluoxetine and review of the literature

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dc.contributor.authorUluğ, Mehmet
dc.contributor.authorUluğ, Nuray Can
dc.contributor.authorÇelen, Mustafa Kemal
dc.contributor.authorGeyik, Mehmet Faruk
dc.contributor.authorAyaz, Celal
dc.date.accessioned2020-04-30T23:32:13Z
dc.date.available2020-04-30T23:32:13Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionGeyik, Mehmet Faruk/0000-0002-0906-0902en_US
dc.descriptionWOS: 000285419600015en_US
dc.description.abstractStevens-Johnson syndrome (SJS) is a rare, life-threatening acute allergic drug reaction presenting with target lesions and blebs of epidermis. Although a variety of etiologies such as infections and underlying malignancies have been implicated as potential causes of SJS, drugs remain the predominant inciting agent. This report presents a SJS case due to combined use of lamotrigine and fluoxetine. A 41-year-old man was admitted to our clinic with fever, skin eruptions (especially on the face and trunk) and lesions around the mouth. The patient's history revealed lamotrigine and fluoxetine use during the previous three weeks for major depression. Dermatological examination revealed a typical clinical picture of SJS; his psychotropic medications were all stopped. While topical and ocular prednisolone (1mg/kg/day) cares were initiated, steroid dosage was reduced within 15 days. The condition of patient rapidly improved through this treatment. Effective management of SJS begins with prompt recognition of the entity, combined with attention to each of the major organs that may be affected, potential comorbidities and withdrawal of all potentially causative drugs. Clinicians should bear in mind the possibility that drugs with potential risk in developing SJS must be used carefully.en_US
dc.identifier.doi10.2478/s11536-010-0001-1en_US
dc.identifier.endpage736en_US
dc.identifier.issn1895-1058
dc.identifier.issue6en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage733en_US
dc.identifier.urihttps://doi.org/10.2478/s11536-010-0001-1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4652
dc.identifier.volume5en_US
dc.identifier.wosWOS:000285419600015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVersitaen_US
dc.relation.ispartofCentral European Journal Of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStevens - Johnson syndromeen_US
dc.subjectLamotrigineen_US
dc.subjectFluoxetineen_US
dc.subjectMedical treatmenten_US
dc.titleStevens-johnson syndrome caused by combined use of lamotrigine and fluoxetine and review of the literatureen_US
dc.typeReview Articleen_US

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