Does propolis have antiviral potential against Myoviridae bacteriophage?

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dc.contributor.authorSonmez, Emine
dc.contributor.authorYildiz, Oktay
dc.contributor.authorAyaz, Naim Deniz
dc.date.accessioned2025-10-11T20:48:47Z
dc.date.available2025-10-11T20:48:47Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe Myoviridae family of bacteriophages presents challenges for antiviral research owing to their structural complexity and ecological significance. While the antibacterial and antiviral properties of Anatolian propolis have been studied, its activity against Myoviridae bacteriophages has not previously been evaluated. This study provides the first comprehensive evaluation of the effectiveness of Anatolian propolis against the M8AEC16 bacteriophage, which is employed as a model to examine interactions with viral-like particles in a biosafe environment. Using RP-HPLC-UV, we identified high concentrations of the potent antiviral compounds ferulic acid and caffeic acid phenethyl ester (CAPE). The propolis samples' bioactive richness is further underscored by their high antioxidant capacity, measured as 144.51 mu M Trolox/g using the FRAP method. Spot test analysis revealed that a propolis concentration of 18.4 mg/mL eradicated 9.91 log pfu/mL of the bacteriophage, demonstrating its efficacy at minimal concentrations. These results suggest that Anatolian propolis could be used as a natural agent to target viral-like pathogens and reduce oxidative stress. This could contribute to the development of alternative antiviral approaches based on natural products.en_US
dc.identifier.doi10.1007/s00217-025-04899-4
dc.identifier.issn1438-2377
dc.identifier.issn1438-2385
dc.identifier.scopus2-s2.0-105016513567en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00217-025-04899-4
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22104
dc.identifier.wosWOS:001572032800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Food Researchand Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectAnatolian propolisen_US
dc.subjectAntiviral activityen_US
dc.subjectMyoviridaeen_US
dc.subjectPhenolic compoundsen_US
dc.subjectAntioxidant capacityen_US
dc.subjectChemical compositionen_US
dc.subjectRP-HPLC-UVen_US
dc.titleDoes propolis have antiviral potential against Myoviridae bacteriophage?en_US
dc.typeArticleen_US

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