Mortality Rate and Prognostic Factors in Neonatal Tetanus: A 3-Year Analysis of Cases Presented to Turkey-Somalia Mogadishu Training and Research Hospital

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dc.authoridDemirel, Mustafa Enes/0000-0001-5187-5737
dc.authoridGudeloglu, Elif/0000-0002-3818-017X
dc.authorwosidDemirel, Mustafa Enes/ABA-2207-2021
dc.contributor.authorGudeloglu, Elif
dc.contributor.authorDemirel, Mustafa Enes
dc.date.accessioned2021-12-01T18:48:02Z
dc.date.available2021-12-01T18:48:02Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjective The aim of this study was to evaluate mortality rate and prognostic factors in neonatal tetanuscasespresented toTurkey-Somalia Mogadishu Training and Research Hospital Methods A total of 35 neonatal tetanus cases presented to Turkey-Somalia Mogadishu Training and Research Hospital between 2014 and 2017 were included in this prospective observational study. Data on demographic, clinical and maternal obstetric characteristics, and laboratory findings including complete blood count and blood biochemistry were recorded in each patient. Study parameters were evaluated with respect to survivorship status, while multiple logistic regression analysis was performed to determine independent predictors of increased mortality risk. Results Overall, mortality occurred in 22 (62.9%) of 35 neonates diagnosed with neonatal tetanus. Tetanus prophylaxis was absent in the majority of neonates, regardless of survivorship status (100.0% in nonsurvivors vs. 84.6% in survivors, p = 0.131). In nonsurvivor versus survivor groups, significantly higher likelihood of constipation (50.0 vs. 7.7%, p = 0.002), contracture (81.8 vs. 46.2%, p = 0.035), and ventilator support (95.4 vs. 53.8%, p = 0.006) as well as significantly lower hemoglobin (14.45 +/- 2.06 vs. 17.15 +/- 1.77, p = 0.003) and potassium (3.50 +/- 0.86 vs. 4.14 +/- 0.93, p = 0.003) levels and neutrophil (3.34 +/- 1.75 vs. 4.47 +/- 1.08, p = 0.047, white blood cell (WBC) (5.54 +/- 2.30 vs. 7.78 +/- 1.70, p = 0.003) and platelet (median [min-max] 133.5 [68-332] versus 196 [123-550], p = 0.006) counts were noted. Presence of contracture (odds ratio [OR]: 14.525, 95% confidence interval [CI]: 1.398-150.870, p = 0.025) and ventilator support (OR: 22.282, 95% CI: 1.269-391.131, p = 0.034) was the independent determinants of increased risk of mortality. Conclusion Our findings emphasize high mortality in neonatal tetanus cases in Somalia along with lack of maternal tetanus prophylaxis in majority of cases. Presence of contractures and ventilator support were significant determinants of poor survival, while factors such as constipation, lower hemoglobin, and potassium levels and lower neutrophil, WBC and platelet counts were also more common among nonsurvivors, albeit not found to be associated with mortality risk in the multivariate analysis.en_US
dc.identifier.doi10.1055/s-0040-1716832
dc.identifier.endpage298en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85091797677en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage293en_US
dc.identifier.urihttps://doi.org/10.1055/s-0040-1716832
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10441
dc.identifier.volume15en_US
dc.identifier.wosWOS:000571462700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal Of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneonatal tetanusen_US
dc.subjecttetanus prophylaxisen_US
dc.subjectmortalityen_US
dc.subjectprognostic factorsen_US
dc.subjectSomaliaen_US
dc.subjectRisk-Factorsen_US
dc.titleMortality Rate and Prognostic Factors in Neonatal Tetanus: A 3-Year Analysis of Cases Presented to Turkey-Somalia Mogadishu Training and Research Hospitalen_US
dc.typeArticleen_US

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