Investigation and Characterization of Novel Biologically Active Secondary Metabolites from Melissa officinalis L.

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dc.authorscopusid15136582600en_US
dc.authorscopusid58899822300en_US
dc.authorscopusid57211212241en_US
dc.authorscopusid58944410500en_US
dc.contributor.authorRasgele, Pinar Goc
dc.contributor.authorYoldas, Pinar Agyar
dc.contributor.authorSipahi, Nisa
dc.contributor.authorUcan, Hilal
dc.date.accessioned2024-08-23T16:07:06Z
dc.date.available2024-08-23T16:07:06Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPlants have very important chemical components, known as secondary metabolites, for the pharmaceutical industry, as well as for the chemical, cosmetics, and agricultural control industries. These secondary metabolites isolated from essential oils are used to obtain the raw material or fragrance component of the drug by semi-synthesis. For this reason, plants have been used to treat many diseases in the past, and their active ingredients are still used in medicine today. Each plant, each drug, contains differences owing to their natural structure. However, making the drug obtained from a plant a standard product is important in terms of using it as a medicine in treatment. Therefore, in our study, both the characterization of secondary metabolites and the antioxidant, antimicrobial and antiproliferative potential of Melissa officinalis were investigated. beta-Citral (30.900%) was the main component of the essential oil. Total phenolic and flavonoid contents of M. officinalis were found to be 923.33 mu g/mL gallic acid equivalent and 1.650 mu g/mL quercetin equivalent. The free radical scavenging percentage of M. officinalis was 42.17%. M. officinalis had antimicrobial activity against Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Candida parapsilosis. In mouse fibroblast cells, the cell viability was found to be 87.50%, 88.235%, and 94.118% respectively, at low doses. In a human breast cancer cell line, it was observed that the cell viability at low concentrations was 77.861%, 85.40%, and 89.474% respectively. The inhibitory concentrations IC50 of M. officinalis calculated for mouse fibroblast and human breast cancer cells in the GraphPad Prism 9.1.1 program were found to be 6229 and 4417 mu g/mL respectively. In conclusion, M. officinalis has high bioactive secondary metabolites such as beta-citral, beta-caryophyllene, 6-methyl-5-hepten-2-one, and cis-1,2-dihydroperillaldehyde, has strong antimicrobial activity, and inhibits viability on breast cancer cells.en_US
dc.description.sponsorshipDuzce University DUBAP project [2020.11.01.1145]en_US
dc.description.sponsorshipThis work was supported by grants from the Duzce University DUBAP project 2020.11.01.1145.en_US
dc.identifier.doi10.1007/s11094-024-03080-7
dc.identifier.endpage1798en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85188131404en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1789en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-024-03080-7
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14493
dc.identifier.volume57en_US
dc.identifier.wosWOS:001186743000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelissa officinalisen_US
dc.subjectcytotoxicityen_US
dc.subjectantiproliferationen_US
dc.subjectL929en_US
dc.subjectMCF-7en_US
dc.subjectessential oilen_US
dc.subjectChemical-Compositionen_US
dc.subjectAntioxidant Activityen_US
dc.subjectEssential Oilen_US
dc.subjectCytotoxicityen_US
dc.titleInvestigation and Characterization of Novel Biologically Active Secondary Metabolites from Melissa officinalis L.en_US
dc.typeArticleen_US

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