Rapid and eco-friendly microextraction procedure based on green hydrophobic deep eutectic solvent for simultaneous determination of five sex hormones from cosmetic samples

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dc.contributor.authorDalmaz, Aslihan
dc.contributor.authorOzak, Sezen Sivrikaya
dc.date.accessioned2025-10-11T20:48:32Z
dc.date.available2025-10-11T20:48:32Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractHormones, which are among the endocrine disruptors, are used in many fields and their use in cosmetic products has recently attracted considerable attention. Despite the negative health consequences, there is no detailed guidance that limits the use of these endocrine disruptors. This study aimed to develop a green hydrophobic deep eutectic solvent (HDES)-based microextraction method for the detection and quantification of sex hormones (progesterone, (3-estradiol, estrone, ethinylestradiol, and testosterone) in different cosmetic products. The best value for extraction recovery was obtained by using DL-menthol and dodecanoic acid as green HDES in a 4:1 mole ratio. Optimization parameters such as HDES volume, pH, sample volume, centrifugation time, mixing type, and mixing time were investigated for cosmetic samples to be used as real samples. Furthermore, the extraction recovery values ranged from 85.7 % to 101.3 % and the detection limit was between 2.33-3.30 ng mL- 1. Additionally, three different greenness methods, namely ComplexGAPI, AGREEprep, and BAGI, were used to evaluate how green the proposed method is in this study. The microextraction procedure developed in this study was successfully applied to five different cosmetic samples that will be used as real samples to detect and determine sex hormones.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK) [123Z666]en_US
dc.description.sponsorshipThis work with a grant number of 123Z666 was supported by The Scientific and Technological Research Council of Turkiye (TUBITAK).en_US
dc.identifier.doi10.1016/j.microc.2024.111979
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85207109044en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.microc.2024.111979
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21949
dc.identifier.volume207en_US
dc.identifier.wosWOS:001344262200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMicrochemical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectSex hormonesen_US
dc.subjectGreen chemistryen_US
dc.subjectHydrophobic deep eutectic solventen_US
dc.subjectCosmeticen_US
dc.subjectComplexGAPI-AGREEprep-BAGIen_US
dc.titleRapid and eco-friendly microextraction procedure based on green hydrophobic deep eutectic solvent for simultaneous determination of five sex hormones from cosmetic samplesen_US
dc.typeArticleen_US

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