Synthesis and in Vitro Antimicrobial Evaluation of Novel Potent Bioactive Heterocyclic Compounds

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dc.authorscopusid58785174600en_US
dc.authorscopusid57189848942en_US
dc.authorscopusid9839684700en_US
dc.authorscopusid25230320600en_US
dc.contributor.authorMacit, Ahsen Zeynep
dc.contributor.authorHasanoglu Ozkan, Elvan
dc.contributor.authorOgutcu, Hatice
dc.contributor.authorNartop, Dilek
dc.date.accessioned2024-08-23T16:04:28Z
dc.date.available2024-08-23T16:04:28Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractIn the present work, the antibacterial and antifungal properties of six new heterocyclic Schiff bases (HSb1, HSb2, HSb3, HSb4, HSb5, HSb6) were evaluated as potential bioactive compounds against the disease-causing pathogenic microorganisms (S.epidermidis, S.aureus, B.cereus RSKK863, E.aerogenes, P.aeroginosa sp., K. pneumonia, S. type H, P.vulgaris, E. coli and (C.albicans Y-1200-NIH). The well-diffusion-method was used to determine the antimicrobial activity. For this purpose, heterocyclic Schiff bases were synthesized by condensation reaction of aldehyde derivatives and thiosemicarbazide derivatives. Spectral analysis techniques (organic elemental analysis, FT-IR,H-1-NMR, HRMS, SEM-EDX) were used to characterize the synthesized compounds. It was determined that all the newly synthesized heterocyclic Schiff bases exhibited sound, high or moderate inhibitory effects on the growth of selected different standard antibiotics. [Graphical Abstract]en_US
dc.description.sponsorshipDzce University Research Funden_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1080/10406638.2023.2298863
dc.identifier.issn1040-6638
dc.identifier.issn1563-5333
dc.identifier.scopus2-s2.0-85180923122en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/10406638.2023.2298863
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14211
dc.identifier.wosWOS:001133032400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPolycyclic Aromatic Compoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectheterocyclic compoundsen_US
dc.subjectschiff basesen_US
dc.subjectbiological activityen_US
dc.subjectpathogenic strainsen_US
dc.subjectthiazoleen_US
dc.subjectCytotoxicity Evaluationen_US
dc.subjectThiosemicarbazonesen_US
dc.titleSynthesis and in Vitro Antimicrobial Evaluation of Novel Potent Bioactive Heterocyclic Compoundsen_US
dc.typeArticleen_US

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