Exercise capacity in sarcoidosis. Study of 29 patients

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dc.contributor.authorAkkoca, Öznur
dc.contributor.authorÇelik, Gökhan
dc.contributor.authorÜlger, Füsun
dc.contributor.authorArbak, Peri
dc.contributor.authorSaryal, Sevgi
dc.contributor.authorKarabıyıkoğlu, Gülseren
dc.contributor.authorAlper, Doğanay
dc.date.accessioned2020-05-01T12:14:13Z
dc.date.available2020-05-01T12:14:13Z
dc.date.issued2005
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000230200400002en_US
dc.descriptionPubMed: 15899162en_US
dc.description.abstractBACKGROUND AND OBJECTIVE: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Aims of this prospective study are to evaluate degree of impairment in pulmonary function tests (PFT), arterial blood gas analysis (ABG), respiratory muscle strength, exercise capacity and correlation of these parameters with radiological stages; to further evaluate the use of cardiopulmonary exercise testing in assessment of extent of pulmonary disease; and to discuss the pathophysiologic mechanisms of limitation in exercise capacity in patients with sarcoidosis. PATIENTS AND METHOD: 29 patients with sarcoidosis were grouped according to their radiological stages (stage I: group 1; stage II, group 2; stage III, group 3). Group 1, 2 and 3 included 11, 13 and 5 patients, respectively. PFT, cardiopulmonary exercise testing and ABG were performed for each patient. RESULTS: Evaluation of all patients showed a significant decrement in exercise capacity. Patients in stage III had decreased diffusing capacity and exercise capacity. There was limitation in exercise capacity in stage I patients who had completely normal spirometry and diffusing capacity. We also found a correlation between radiological stages of the disease and exercise capacity, diffusing capacity and ABG. CONCLUSIONS: Exercise capacity is impaired also in early stages of sarcoidosis and it was found to be the earliest impaired physiological parameter in sarcoid patients. Exercise intolerance, having mutifactorial basis, is correlated with radiological stages. Circulatory impairment and impaired heart rate response to exercise have effects on limitation in exercise capacity. Especially in advanced radiological stages of disease, ventilatory and gas exchange impairment also seems to be effective on limiting exercise in patients with sarcoidosis.en_US
dc.identifier.doi10.1157/13075090en_US
dc.identifier.endpage689en_US
dc.identifier.issn0025-7753
dc.identifier.issn1578-8989
dc.identifier.issue18en_US
dc.identifier.startpage686en_US
dc.identifier.urihttps://doi.org/10.1157/13075090
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6350
dc.identifier.volume124en_US
dc.identifier.wosWOS:000230200400002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofMedicina Clinicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsarcoidosisen_US
dc.subjectexercise capacityen_US
dc.subjectpulmonary function testsen_US
dc.titleExercise capacity in sarcoidosis. Study of 29 patientsen_US
dc.typeArticleen_US

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