Intralesional Epidermal Growth Factor for Diabetic Foot Ulcers

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dc.authoriddüzgün, Ali Cemal/0000-0003-0491-913X
dc.authoridILKELI, EKIN/0000-0003-0302-4721
dc.authorwosiddüzgün, Ali Cemal/HKW-4738-2023
dc.contributor.authorİlkeli, Ekin
dc.contributor.authorDemircan, Fethiye Berna Göktaş
dc.contributor.authorDüzgün, Ali Cemal
dc.contributor.authorArabacı, Hakan
dc.contributor.authorUysal, Ayhan
dc.contributor.authorKanko, Muhip
dc.date.accessioned2023-07-26T11:51:20Z
dc.date.available2023-07-26T11:51:20Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: To determine the role of the intralesional recombinant epidermal growth factor (rEGF) in the healing and prevention of extremity amputation in advanced diabetic foot ulcer patients. Study Design: Observational study. Place and Duration of Study: Department of Cardiovascular Surgery, Duzce State Hospital, Duzce, Turkey, between November 2018 and September 2019. Methodology: A total of 58 patients with diabetic foot ulcers that were treated at the study place were enrolled. The lesions were graded with Wagner Classification System. EGF (75 microg of Heberprot-P) vials were stored at +4 degrees C and cold-chain requirements were followed. EGF 5 mL was dissolved with 0.09% saline solution; and 0.5-1 ml of the solution was injected into the tissues and edge of the lesions regularly. The data was evaluated at the end of two years of the treatment period. The primary objective was wound healing, formation of granulation tissue; and the secondary objective was the prevention of lower extremity amputation. Results: Diabetic foot ulcers wound healing was achieved in 93.1% (n=54) of patients with the formation of granulation tissue. The complete recovery was observed in 94.1% (n=32) of the patients who had Grade III and IV lesions. Lower extremity amputation was performed in two (3.4%) subjects. The lesions of two patients required flap surgery. The most common adverse events were tremor and syncope. Conclusion: Recombinant epidermal growth factor is highly effective for the treatment of diabetic foot ulcers and prevention of extremity amputation. Intralesional rEGf provides efficient and safe wound healing/closure in patients with diabetic foot ulcers.en_US
dc.identifier.doi10.29271/jcpsp.2022.03.278
dc.identifier.endpage282en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue3en_US
dc.identifier.pmid35148575en_US
dc.identifier.startpage278en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2022.03.278
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12540
dc.identifier.volume32en_US
dc.identifier.wosWOS:000754226900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİlkeli, Ekin
dc.institutionauthorDemircan, Fethiye Berna Göktaş
dc.institutionauthorArabacı, Hakan
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal of The College of Physicians and Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAmputation; Epidermal Growth Factor; Diabetic Foot; Wound Healingen_US
dc.subjectAdvanced Glycationen_US
dc.titleIntralesional Epidermal Growth Factor for Diabetic Foot Ulcersen_US
dc.typeArticleen_US

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