Protective effects of lupeol on acute exercise-related oxidativestress in male rats

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dc.authoridGOK, Ali/0000-0003-4103-9537;
dc.contributor.authorOzdemir, Emrah
dc.contributor.authorCoknaz, Hakki
dc.contributor.authorSener, Sila oezlem
dc.contributor.authorOzgen, Ufuk
dc.contributor.authorGok, Ali
dc.date.accessioned2025-10-11T20:47:51Z
dc.date.available2025-10-11T20:47:51Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats.Rats were randomly selected and divided into four groups (n=6/group): Control, exercise, lupeol and exercise+lupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), coenzyme Q10 (CoQ10) and alpha-lipoic acid (ALA) and oxidative stress levels in serum samples were measured.As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed tooxidative stress inhibits free radicals formed by stress.In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damageen_US
dc.identifier.doi10.29228/jrp.875
dc.identifier.endpage2016en_US
dc.identifier.issn2630-6344
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85213037887en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2008en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.875
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21614
dc.identifier.volume28en_US
dc.identifier.wosWOS:001407427700016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Fac Pharmacyen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectAntioxidanten_US
dc.subjectexerciseen_US
dc.subjectfree radicalen_US
dc.subjectlupeolen_US
dc.subjectoxidative stressen_US
dc.titleProtective effects of lupeol on acute exercise-related oxidativestress in male ratsen_US
dc.typeArticleen_US

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