Increased sister chromatid exchanges in patients with gastrointestinal cancers and in their first-degree relatives

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dc.contributor.authorTurgut, Taner
dc.contributor.authorYaşar, Mehmet
dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorErtaş, Ertuğrul
dc.contributor.authorSılan, Fatma
dc.date.accessioned2020-04-30T13:32:36Z
dc.date.available2020-04-30T13:32:36Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractGastrointestinal Cancers (GICs) are the most important causes of mortality and morbidity in industrialized world. Sister chromatid exchange (SCE), as an index of chromosomal instability, involves cancer. The aim of this study is to determine whether SCE frequency is a heritable factor for GIC or not. The study groups consisted of 15 gastrointestinal carcinoma patients, 13 patient relatives and 15 healthy subjects as the control group. After collection of 2 ml peripheral blood, lymphocytes were cultured for 3 days and sister chromatid exchange (SCE), mitotic index, and replication index were analyzed. SCE was significantly increased (p<0.01) in patients (16.06±22.37) and in their relatives (5.23±2.64) compared with controls (3.51±1.58). There was no significant difference between patients' relatives and control group in terms of the incidence of SCE frequency. Mitotic index was significantly decreased (p<0.05, p<0.01) in patients (5.4±3.13) compared with healthy relatives (7.15±2.15) and controls (9.00±2.26). Replication index was also significantly lower (p<0.01) in patients (1.39±0.35) and in their relatives (1.7±0.21) compared with controls (2.04±1.13). The results of this study indicate that SCE is a heritable factor for GICs. Increased SCE reflects genomic instability, which is an important factor in carcinogenesis. Although the most putative factors causing genomic instability are epigenetics marks, further studies in combination with epigenetic modifications are needed using more subjects.en_US
dc.identifier.doi10.15197/sabad.1.11.46en_US
dc.identifier.endpage98en_US
dc.identifier.issn1304-3889
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage94en_US
dc.identifier.urihttps://dx.doi.org/10.15197/sabad.1.11.46
dc.identifier.urihttps://hdl.handle.net/20.500.12684/364
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTIP ARASTIRMALARI DERNEGIen_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChromosomal instability; Gastrointestinal cancer; Sister chromatid exchangeen_US
dc.titleIncreased sister chromatid exchanges in patients with gastrointestinal cancers and in their first-degree relativesen_US
dc.title.alternativeBirinci derecede akrabalarda gastrointestinal kanserli hastalarda artmış kromatid de?işimleren_US
dc.typeArticleen_US

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