The Effects of Acute and Chronic Metformin Treatment on Penicillin Induced Epileptiform Activity in Rats

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dc.contributor.authorKılıç, Ümit
dc.contributor.authorBeyazçiçek, Ersin
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorDemir, Şerif
dc.contributor.authorBeyazçiçek, Özge
dc.date.accessioned2023-07-26T11:53:48Z
dc.date.available2023-07-26T11:53:48Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: The aim of this study is to investigate acute and chronic administered metformin on epileptiform activity induced by penicillin and antioxidant activity in rats. Methods: Eighty-four adult male Wistar albino rats were used in this study. The rats were divided into two large groups as acute and chronic groups, and later on each group was divided into different subgroups as control, sham, penicillin, metformin 100 mg/kg (Met_100), 200 mg/kg (Met_200) and only metformin 200 mg/kg (OMet_200) intraperitoneally. The substances were applied to the chronic groups for 21 days, while acute groups received them just before the initiation of epileptiform activity. In the present study, onset of first epileptiform activity, spike wave frequency and amplitude, and superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) parameters were evaluated. Results: No epileptiform activity was observed in the control, sham, and OMet_200 groups. When metformin doses of 100 mg/kg, 200 mg/kg were compared with the penicillin group in both acute and chronic groups, the onset of first epileptiform activity was prolonged, spike wave frequency and spike wave amplitude decreased significantly. SOD, CAT and GPx levels were found to be significantly different in the acute and chronic metformin groups compared to the penicillin group. Conclusion: In conclusion, this study shows that metformin can decrease epileptic seizures and increase the level of antioxidant enzymes and it can be used in the treatment of epilepsy in the future.en_US
dc.identifier.doi10.4274/jarem.galenos.2022.25238
dc.identifier.endpage98en_US
dc.identifier.issn2146-6505
dc.identifier.issn2147-1894
dc.identifier.issue2en_US
dc.identifier.startpage87en_US
dc.identifier.trdizinid1128396en_US
dc.identifier.urihttp://doi.org/10.4274/jarem.galenos.2022.25238
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1128396
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12606
dc.identifier.volume12en_US
dc.identifier.wosWOS:001129954000008en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKılıç, Ümit
dc.institutionauthorBeyazçiçek, Ersin
dc.institutionauthorDemir, Şerif
dc.institutionauthorBeyazçiçek, Özge
dc.language.isoenen_US
dc.relation.ispartofJAREMen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.titleThe Effects of Acute and Chronic Metformin Treatment on Penicillin Induced Epileptiform Activity in Ratsen_US
dc.typeArticleen_US

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