CdSeTe quantum dot based fluorescence sensor systems for detection of vitamin C, folic acid and glucose

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dc.authoridElibol, Erdem/0000-0003-0328-5534
dc.authoridBakay, Melahat Sevgul/0000-0001-6931-3281
dc.contributor.authorBakay, Melahat Sevgul
dc.contributor.authorElibol, Erdem
dc.contributor.authorCadirci, Musa
dc.date.accessioned2025-10-11T20:48:32Z
dc.date.available2025-10-11T20:48:32Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe levels of metabolites in the human body provide significant clues for the diagnosis, staging, and therapy planning of diseases. Recently, fluorescence-based metabolite detection methods have become popular thanks to their important advantages such as using less sample, not requiring prior preparation, and responding quickly. In this regard, quantum dots (QDs) are unique materials in metabolite detection studies due to their well-known fluorescence-emitting structures, high luminescence, tunable size, and high absorption cross-section ratio. In this experiment, we synthesized the mercaptopropionic acid (MPA) capped CdSeTe-alloy QDs and investigated their metabolite detection performance using vitamin C (VitC), folic acid (FA) and glucose (Glu). Under the optimized conditions (pH, QD concentration and incubation times), the quenching fluorescent responses were obtained from metabolite-added CdSeTe QD solution which ascribed to the Forster resonance energy transfer (FRET) mechanism. The linearity ranges and limit of detection (LOD) values for VitC, FA and Glu were determined. The presented method has also been applied to quantify the amount of metabolites in human blood serum samples in the linear ranges of 10-20 mu g/mL for CVit, 7.5-20 ng/mL for FA, and 0.25-1.5 mg/mL for glucose, with an accuracy of over 95 %. This sensor system has also shown a noteworthy advantage regarding sensitive, selective, reliable and cost-effective metabolite detection technique.en_US
dc.description.sponsorshipDuzce University Scientific Research Project [BAP-2022.06.03.1278]en_US
dc.description.sponsorshipTUBITAK [122F434]en_US
dc.description.sponsorshipThis study was supported by Duzce University Scientific Research Project numbered BAP-2022.06.03.1278. E.E was supported by TUBITAK with a project number of 122F434.en_US
dc.identifier.doi10.1016/j.microc.2024.111543
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85203468073en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.microc.2024.111543
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21950
dc.identifier.volume206en_US
dc.identifier.wosWOS:001311706900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMicrochemical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectFluorescence sensoren_US
dc.subjectFolic aciden_US
dc.subjectGlucoseen_US
dc.subjectQuantum dotsen_US
dc.subjectVitamin Cen_US
dc.titleCdSeTe quantum dot based fluorescence sensor systems for detection of vitamin C, folic acid and glucoseen_US
dc.typeArticleen_US

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