Decreased Oxidative Stress Markers in Patients with Active and Generalized Vitiligo

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dc.authoridÖzcan, Yunus/0000-0002-2295-1152
dc.authorwosidÖzcan, Yunus/AAD-4832-2021
dc.contributor.authorOzcan, Yunus
dc.contributor.authorKaragun, Ebru
dc.contributor.authorAlpay, Merve
dc.date.accessioned2023-04-10T20:31:00Z
dc.date.available2023-04-10T20:31:00Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractObjective: Oxidative stress has been shown to play a role in the pathophysiology of several diseases, making it a popular yet contentious research area. There is some evidence that selective melanocyte destruction may have developed in vitiligo patients as a result of elevated oxidative stress. The purpose of this study is to investigate the impact of oxidative stress on lipid, protein, and nucleic acid metabolism in vitiligo patients. Methods: We used ELISA method to measure serum oxidative stress markers in patients with generalized vitiligo who had newly formed lesions in the previous three months but had not been treated, as well as healthy controls. Malondialdehyde (MDA), 2,4-dinitrophenyl hydrazone (DNPH), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and uncoupling protein 2 (UCP2) levels were measured to assess the influence of reactive oxygen derivatives on lipid, protein, nucleic acid metabolism, and mitochondria, respectively. Results: The study included 84 participants, including 64 active generalized vitiligo patients and 20 healthy controls with similar age and gender distribution. In the serum of vitiligo patients, we detected significantly lower levels of MDA (ng/mL, mean +/- SD=12 +/- 19; 33.4 +/- 35.9), DNPH (ng/mL, mean +/- SD=2 +/- 3.1; 6 +/- 7.4), 8-OHdG (ng/mL, mean +/- SD=11.7 +/- 17.9; 32.7 +/- 37) and UCP2 (ng/mL, mean +/- SD=8.7 +/- 13.7; 21.5 +/- 28.4. Conclusions: Although there is significant evidence that oxidative stress plays a role in the pathophysiology of vitiligo, the studies should be interpreted cautiously due to the heterogeneity in the methodology, complexity of the oxidative stress pathways, and potential publication bias. Large-scale studies using a standardized methodology are required to determine how significant oxidative stress is in the core pathophysiology of vitiligo and which pathways it primarily affects.en_US
dc.identifier.doi10.18521/ktd.880577
dc.identifier.endpage322en_US
dc.identifier.issn1309-3878
dc.identifier.issue2en_US
dc.identifier.startpage317en_US
dc.identifier.trdizinid1121010en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.880577
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12019
dc.identifier.volume14en_US
dc.identifier.wosWOS:000821703000005en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeoxyguanosine; Malondialdehyde; Uncoupling Protein 2; Vitiligoen_US
dc.subjectUncoupling Proteins; Dna-Damage; Biomarkers; Antioxidants; Metaanalysis; Productsen_US
dc.titleDecreased Oxidative Stress Markers in Patients with Active and Generalized Vitiligoen_US
dc.typeArticleen_US

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