Neurotoxic effects of ketamine and different doses of ropivacaine administered intrathecally in rabbits

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dc.contributor.authorSezen, Gülbin
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorGüven, Aysel
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorSevinç, Özdemir
dc.contributor.authorKaragöz, İbrahim
dc.date.accessioned2020-04-30T13:32:51Z
dc.date.available2020-04-30T13:32:51Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Although a variety of anesthetic medicines are used intrathecally, experimental neurotoxic studies on these drugs are not sufficient. In our study, we used immunocytochemical examination to assess the neurotoxic potential of ketamine and different doses of ropivacaine administered intrathecally. Material and Methods: Thirty rabbits were divided into five groups which were inserted spinal catheters under anesthesia. Each group received in a volume of 0.3 ml, as follows: the R0.2 group received 0.2% ropivacaine, the R0.75 group received 0.75% ropivacaine, the R1 group received 1.0% ropivacaine, the K group received preservative-free S (+) ketamine and the C group received 0.9% NaCl. The onset and duration of action were recorded by using Motor Dysfunction Index (MDI). Rabbits were observed for five days and then euthanasized. After catheters were removed, brains and spinal tissue samples were evaluated by light microscopy and immunocytochemical examination. Results: The longest onset of action was observed in the K group. Among the ropivacaine groups, the onset of action diminished and the duration of action extended with an increase in dose significantly. There was axonal degeneration in the R1 group, but this finding not reach significance. In the ketamine group, significant neuronal degeneration and reduction in number of neurons in the brain sections were observed. In the 1% ropivacaine group, a relative increase in neurofilament intensity was detected using immunocytochemical assessments in the medulla spinalis and brain sections. Conclusion: The intrathecal applications of 1% ropivacaine and ketamine can induce neurotoxic damage, despite a lack of observed functional neurologic deficits. © 2013 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2012-32801en_US
dc.identifier.endpage1111en_US
dc.identifier.issn1300-0292
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1103en_US
dc.identifier.urihttps://dx.doi.org/10.5336/medsci.2012-32801
dc.identifier.urihttps://hdl.handle.net/20.500.12684/461
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInjections; Ketamine; Ropivacaine; Spinalen_US
dc.titleNeurotoxic effects of ketamine and different doses of ropivacaine administered intrathecally in rabbitsen_US
dc.title.alternativeTavşanlarda İntratekal uygulanan ketamin ve farklı dozlarda ropivakainin nörotoksik etkilerien_US
dc.typeArticleen_US

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