Evaluation of HLA-B51 frequency and its relationship with clinical findings in patients with Behcet's disease: 4-year analysis in a single center

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dc.contributor.authorSultanoğlu, Tuba Erdem
dc.contributor.authorEröz, Recep
dc.contributor.authorAtaoğlu, Safinaz
dc.date.accessioned2023-07-26T11:54:56Z
dc.date.available2023-07-26T11:54:56Z
dc.date.issued2023
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalıen_US
dc.description.abstractBackgroundThe clinical findings of Behcet's disease (BD) differ according to the country and race investigated. The most important genetic factor known in the pathogenesis of BD is HLA-B51, and this positivity is high in countries on the Silk Road where BD is as frequent as it is in Turkey. Although the positivity of HLA B51 is proven to be high in Turkey, there are no studies in the area of the western Black sea demonstrating its relation to the demographic. We aimed to investigate the association of HLA-B51 positivity in Turkish patients diagnosed as having BD and the relationship between the demographic and clinical findings of the patients.ResultsIn this descriptive, cross-sectional study, a convenience sample of adults with BD was obtained from an outpatient clinic of a university hospital in Turkey between January 2018 and January 2022. Patients were diagnosed as having BD according to the criteria of the International BD Study Group, and the patients' sociodemographic and clinical characteristics were recorded retrospectively. Demographic data and the frequency of clinical findings were compared between patients who were HLA-B51-positive and HLA-B51-negative. Sixty patients (55.6%) were HLA-B51-positive. Oral ulceration, genital ulceration, thrombophlebitis, and family history of BD were found to be higher in patients who were HLA-B51-positive. Erythema nodosum, papulopustular eruption, pathergy positivity, arthritis, and ocular involvement were less frequent in patients with HLA-B51 positivity. However, there were no statistically significant differences according to the frequency of clinical findings between the HLA-B51-positive and HLA-B51-negative groups.ConclusionsHLA B51 positivity is not diagnostic of BD; however, it may affect clinical phenotypes. Although oral and genital ulcerations, thrombophlebitis, and positive family history of BD were found to be common in patients with HLA-B51 positivity, this relationship could not reach statistical significance.en_US
dc.identifier.doi10.1186/s43166-023-00181-1
dc.identifier.issn1110-161X
dc.identifier.issn2090-3235
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85170352611en_US
dc.identifier.urihttps://doi.org/10.1186/s43166-023-00181-1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12961
dc.identifier.volume50en_US
dc.identifier.wosWOS:000942756300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorSultanoğlu, Tuba Erdem
dc.institutionauthorAtaoğlu, Safinaz
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofEgyptian Rheumatology and Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectBehcet Disease; Clinical Manifestations; Hla-B51; Turkeyen_US
dc.subjectTurkish Patients; Association; Hla-B-Asterisk-51; Manifestations; Gender; Sex; Ageen_US
dc.titleEvaluation of HLA-B51 frequency and its relationship with clinical findings in patients with Behcet's disease: 4-year analysis in a single centeren_US
dc.typeArticleen_US

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