Exploring the ameliorative effects of hypericum Scabrum l. On a surgically-induced endometriosis rat model and its phytochemical LC-MS/MS- profile

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dc.authoridYILMAZ, Mustafa Abdullah/0000-0002-4090-7227;en_US
dc.authorscopusid56020070400en_US
dc.authorscopusid25121451300en_US
dc.authorscopusid17343813200en_US
dc.authorscopusid54893403000en_US
dc.authorscopusid57201261233en_US
dc.authorscopusid56486842000en_US
dc.authorscopusid57190762043en_US
dc.authorwosidYILMAZ, Mustafa Abdullah/ABC-3328-2021en_US
dc.authorwosidBattal, Abdulhamit/JFS-6886-2023en_US
dc.contributor.authorIlhan, Mert
dc.contributor.authorBattal, Abdulhamit
dc.contributor.authorKaptaner, Burak
dc.contributor.authorDogan, Abdulahad
dc.contributor.authorDonmez, Fatih
dc.contributor.authorYilmaz, Mustafa abdullah
dc.contributor.authorEroglu, Huseyin
dc.date.accessioned2024-08-23T16:03:39Z
dc.date.available2024-08-23T16:03:39Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractEndometriosis is described as the existence and expansion of functional endometrial-like tissues in another part of the uterine cavity. It affects not only postmenopausal women but also teenagers after menarche, causing subfertility, dysmenorrhea and severe pelvic pain. Since no specific treatment is acknowledged for this disease, the present study aimed to investigate the efficacy of H. scabrum in a surgically-induced endometriosis rat model. In order to test the efficacy of H. scabrum on endometriosis, n-hexane, ethyl acetate (EtOAc), methanol (MeOH) and aqueous extracts were prepared from the aerial parts of H. scabrum. The cytokine levels, antioxidant enzyme activities, the contents of malondialdehyde (MDA) and glutathione (GSH) and histopathological analyses were evaluated. In order to reveal the potential active compounds, liquid chromatography-mass/mass spectroscopy (LC-MS/MS) analysis was performed on the MeOH extract who presentedthe highest activity. The MeOH extract significantly decreased the adhesion scores, endometriotic implant volumes, cytokine levels and the antioxidant parameters. Furthermore, histological procedures supported those findings. According to LC-MS/MS analysis of the MeOH extract, the major compounds were mostly phenolic acids and flavonoids. We concluded that the MeOH extract from H. scabrum aerial parts could be used for the treatment of endometriosis, and its activity could be attributed to the chlorogenic acid and quercetin, detected in the highest amounts.en_US
dc.description.sponsorshipVan Yuezuencue Yil University Scientific Research Project Commission [TYD-2021-9253]en_US
dc.description.sponsorshipThis research was funded by Van Yuezuencue Yil University Scientific Research Project Commission (Grant number: TYD-2021-9253) .en_US
dc.identifier.doi10.31925/farmacia.2023.4.7
dc.identifier.endpage721en_US
dc.identifier.issn0014-8237
dc.identifier.issn2065-0019
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85168520120en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage710en_US
dc.identifier.urihttps://doi.org/10.31925/farmacia.2023.4.7
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13847
dc.identifier.volume71en_US
dc.identifier.wosWOS:001053154200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Stiinte Farmaceutice Romaniaen_US
dc.relation.ispartofFarmaciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantioxidanten_US
dc.subjectcytokinesen_US
dc.subjectendometriosisen_US
dc.subjectethnopharmacologyen_US
dc.subjectHypericum scabrumen_US
dc.subjectLC-MS/MSen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectPeritoneal-Fluiden_US
dc.subjectOxidative-Stressen_US
dc.subjectWomenen_US
dc.titleExploring the ameliorative effects of hypericum Scabrum l. On a surgically-induced endometriosis rat model and its phytochemical LC-MS/MS- profileen_US
dc.typeArticleen_US

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