Carvacrol: A Protective Agent Against Cadmium Nitrate Toxicity in Allium cepa L.

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dc.contributor.authorRasgele, Pinar G. O. C.
dc.contributor.authorKaraguzel, Ahsen
dc.contributor.authorUgras, Serpil
dc.contributor.authorEmire, Zuhal
dc.date.accessioned2025-10-11T20:48:44Z
dc.date.available2025-10-11T20:48:44Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractMonoterpenes are isoprene derivatives that contain conjugated double bonds and are synthesized in many plant families. In this study, the aim was to measure the protective effect of carvacrol, one of these monoterpenes, against cadmium nitrate-induced oxidative stress using parameters such as morphologic, cytogenetic, and antioxidant activity via the Allium cepa L. model. The control group was treated with distilled water, while the treatment groups were treated with low (25 ppm) and high (100 ppm) doses of carvacrol, cadmium nitrate (80 ppm), carvacrol (25 ppm) + cadmium nitrate (80 ppm), and carvacrol (100 ppm) + cadmium nitrate (80 ppm) for 96 h. Improvements were observed in the adverse effects induced by cadmium nitrate with increasing doses of carvacrol. When the MI values of carvacrol at concentrations of 25 and 100 ppm were compared with the negative control, a statistically significant increase was observed. Furthermore, the high dose (100 ppm) of carvacrol co-administered with cadmium nitrate caused a decrease in the number of abnormalities induced by cadmium nitrate. It was observed that the activities of superoxide dismutase and catalase increased in the cadmium nitrate. However, in the samples where cadmium nitrate and carvacrol were co-administered, the activities of superoxide dismutase and catalase decreased depending on the concentration. As a result, it was determined that none of the concentrations of carvacrol had cytotoxic and genotoxic effects, and carvacrol at a concentration of 100 ppm exhibited a protective effect against the toxicity induced by cadmium nitrate.en_US
dc.identifier.doi10.1007/s11094-025-03412-1
dc.identifier.endpage444en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-105012723983en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage436en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-025-03412-1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22064
dc.identifier.volume59en_US
dc.identifier.wosWOS:001545100000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectheavy metalen_US
dc.subjectcarvacrolen_US
dc.subjectmitotic abnormalityen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectcatalaseen_US
dc.titleCarvacrol: A Protective Agent Against Cadmium Nitrate Toxicity in Allium cepa L.en_US
dc.typeArticleen_US

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