EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trial

Basit Öğe Kaydı
dc.authorscopusid56666558100
dc.authorscopusid8655248000
dc.authorscopusid57202573860
dc.authorscopusid6504325029
dc.authorscopusid16203350300
dc.authorscopusid57869538800
dc.authorscopusid57869864700
dc.contributor.authorWeiss, R.
dc.contributor.authorSaadat-Gilani, K.
dc.contributor.authorKerschke, L.
dc.contributor.authorWempe, C.
dc.contributor.authorMeersch, M.
dc.contributor.authorZarbock, A.
dc.contributor.authorMakhloufi, H.
dc.date.accessioned2023-07-26T11:50:50Z
dc.date.available2023-07-26T11:50:50Z
dc.date.issued2021
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalıen_US
dc.description.abstractIntroduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. Methods and analysis EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. Ethics and dissemination EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369. ©en_US
dc.description.sponsorshipBaxter International; Deutsche Forschungsgemeinschaft, DFG: KFO342/1, ME5413/1-1, ZA 428/21-1, ZA428/18-1en_US
dc.description.sponsorshipFunding This work was supported by an unrestricted research grant from Baxteren_US
dc.description.sponsorshipThis work was supported by an unrestricted research grant from Baxter and the German Research Foundation (KFO342/1, ZA428/18-1, and ZA 428/21-1 to AZ; ME5413/1-1 to MM).en_US
dc.identifier.doi10.1136/bmjopen-2021-055705
dc.identifier.issn2044-6055
dc.identifier.issue12en_US
dc.identifier.pmid35588372en_US
dc.identifier.scopus2-s2.0-85122637577en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1136/bmjopen-2021-055705
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12440
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarka, Özlem Ersoy
dc.institutionauthorŞenoğlu, Gizem Demir
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofBMJ Openen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectacute renal failureen_US
dc.subjectadult intensive & critical careen_US
dc.subjectchronic renal failureen_US
dc.subjectepidemiologyen_US
dc.subjectsurgeryen_US
dc.subjectbiological markeren_US
dc.subjectacute kidney failureen_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectclinical outcomeen_US
dc.subjectcohort analysisen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjectfollow upen_US
dc.subjecthigh dependency uniten_US
dc.subjecthospitalizationen_US
dc.subjecthumanen_US
dc.subjectintensive care uniten_US
dc.subjectkidney diseaseen_US
dc.subjectmajor clinical studyen_US
dc.subjectmajor surgeryen_US
dc.subjectmaleen_US
dc.subjectmortalityen_US
dc.subjectmulticenter studyen_US
dc.subjectobservational studyen_US
dc.subjectprospective studyen_US
dc.subjectrenal replacement therapyen_US
dc.subjectrisk factoren_US
dc.subjectacute kidney failureen_US
dc.subjectincidenceen_US
dc.subjectmulticenter study (topic)en_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectCohort Studiesen_US
dc.subjectHumansen_US
dc.subjectIncidenceen_US
dc.subjectMulticenter Studies as Topicen_US
dc.subjectObservational Studies as Topicen_US
dc.subjectProspective Studiesen_US
dc.subjectRenal Replacement Therapyen_US
dc.titleEPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trialen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
12440.pdf
Boyut:
659.28 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu