Effects Of Etofenamate And Methylprednısolone On Spınal Cord Injury
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Dosyalar
Tarih
2015
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışma omurilik hasarını izleyen ikincil olaylar üzerine etofenamate' ın etkisini değerlendirmek ve bu etkiyi metilprednizolon etkisi ile karşılaştırmak amacıyla yapılmıştır. Toplam 31 erkek Wistar-Albino sıçan kullanılmıştır. 50g-cm etkili ağırlık düşürme modeli deneysel omurilik hasarı oluşturmak için kullanılmıştır. Sıçanlar üç çalışma koluna randomize olarak ayrılmışlardır (saline, etofenamate 20 mg/kg, metilprednizolon 30 mg/kg). Hasarın 6.saatinde anestezi altında elektrofizyolojik değerlendirme yapılmış ve sonra histopatolojik inceleme için sıçanlar feda edilmiştir. Hematoksilin-eozin boyaması ile ışık mikroskopu altında değerlendirilmiştir. Etofenamate, metilprednizolon ile karşılaştırıldığında histopatolojik olarak daha faydalı bulunmuştur, fakat bu durum elektrofizyolojik olarak doğrulanamamıştır. Etofenamate omurilik hasarının tedavisinde ümit verici olabilir
This study evaluates the effects of etofenamate on secondary damage following a spinal cord injury and compares the effects with those of methylprednisolone. A total of 31 male Wistar-Albino rats were used. A weight-drop model was utilized for the experimental spinal cord injury and a 50g-cm impact was applied on the spinal cord. Rats were randomly assigned to one of the three study arms (saline, etofenamate 20 mg/kg, methylprednisolone 30 mg/kg). At the sixth hour of injury electrophysiological evaluations were conducted under anesthesia, and then rats were sacrificed for histopathology. Hematoxylin and eosin staining were applied to the specimens and evaluated under light microscopy. Etofenamate revealed more beneficial results in histopathological evaluations when compared with methylprednisolone, but these favorable results have not been confirmed by electrophysiological measurements. Etofenamate may be a promising agent in the medical treatment of spinal cord injury
This study evaluates the effects of etofenamate on secondary damage following a spinal cord injury and compares the effects with those of methylprednisolone. A total of 31 male Wistar-Albino rats were used. A weight-drop model was utilized for the experimental spinal cord injury and a 50g-cm impact was applied on the spinal cord. Rats were randomly assigned to one of the three study arms (saline, etofenamate 20 mg/kg, methylprednisolone 30 mg/kg). At the sixth hour of injury electrophysiological evaluations were conducted under anesthesia, and then rats were sacrificed for histopathology. Hematoxylin and eosin staining were applied to the specimens and evaluated under light microscopy. Etofenamate revealed more beneficial results in histopathological evaluations when compared with methylprednisolone, but these favorable results have not been confirmed by electrophysiological measurements. Etofenamate may be a promising agent in the medical treatment of spinal cord injury
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26
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4
