Effects of thymoquinone on alpha-amanitin induced hepatotoxicity in human C3A hepatocytes

Basit Öğe Kaydı
dc.authoridkaya, ertugrul/0000-0003-0081-682X
dc.authoridYılmaz, İsmail/0000-0002-4474-9617
dc.authorwosidkaya, ertugrul/C-1505-2013
dc.contributor.authorKatırcı, Yavuz
dc.contributor.authorYılmaz, İsmail
dc.contributor.authorKaya, Ertuğrul
dc.date.accessioned2023-07-26T11:57:19Z
dc.date.available2023-07-26T11:57:19Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.description.abstractThymoquinone (TQ) has shown hepatoprotective effects in various experimental studies. We aimed to investigate the possible beneficial effects of TQ regarding its prevention of alpha-amanitin induced hepatotoxicity in human C3A hepatocytes. After administering alpha-amanitin in a concentrations of 1 and 10 mu g/mL on the cells in a hepatocyte cell line, TQ was administered in various concentrations (10, 5, 1, 0.5, 0.1, 0.05, 0.01, 0.005 mu g/mL). The MTT test was used to determine cell viability. For the groups given only TQ at various concentrations, the cell viability rates at 48 hours post-administration were found at 82.6, 98.3, 102.1, 102.5, 99.4, 99.4, 101.9 and 106.3%, respectively. For the group with 1 mu g/mL alpha-amanitin and various TQ concentrations, the cell viability rates were found at 74.6, 88.5, 87.4, 88.7, 85.7, 86.8, 88.4, and 92.9%, respectively. For the group with 10 mu g/mL alpha-amanitin and various TQ concentrations, the cell viability rates for each TQ subgroup were found at 65.2, 79.2, 81.4, 81.1, 81.8, 81.8, 82.2 and 91.9%, respectively. Our study is the first in vitro study that investigates TQ's effects on alpha-amanitin induced hepatotoxicity. Although TQ had beneficial effect in low doses did not significantly increase cell viability in liver damage due to alpha-amanitin toxicity.en_US
dc.identifier.doi10.1590/s2175-97902022e191072
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85134557982en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902022e191072
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13123
dc.identifier.volume58en_US
dc.identifier.wosWOS:000836190400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaya, Ertuğrul
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectThymoquinone; Alpha-Amanitin; Hepatotoxicity; Mtt Assay; C3a Human Hepatocyte Cell Lineen_US
dc.subjectNigella-Sativa; Oxidative Stress; N-Acetylcysteine; Urtica-Dioica; Toxicity; Mice; Purification; Constituent; Generation; Phalloidesen_US
dc.titleEffects of thymoquinone on alpha-amanitin induced hepatotoxicity in human C3A hepatocytesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
13123.pdf
Boyut:
624.79 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu