In vitro biological activities and preliminary phytochemical screening of different extracts from Achillea sintenisii Hub- Mor

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dc.authoridALKAN, FULYA ÜSTÜN/0000-0003-1782-9467
dc.authoridAnlaş, Ceren/0000-0002-7997-016X
dc.authorwosidALKAN, FULYA ÜSTÜN/D-7406-2019
dc.authorwosidAnlaş, Ceren/D-4097-2019
dc.contributor.authorAnlaş, Ceren
dc.contributor.authorBakirel, Tülay
dc.contributor.authorUstuner, Oya
dc.contributor.authorUstun-Alkan, Fulya
dc.contributor.authorDiren-Sığırcı, Belgi
dc.contributor.authorKoca Çalışkan, Ufuk
dc.contributor.authorMancak-Karakuş, Methiye
dc.date.accessioned2023-07-26T11:50:51Z
dc.date.available2023-07-26T11:50:51Z
dc.date.issued2023
dc.departmentDÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThis study was designed to investigate in vitro biological activities and phytochemical composition of aqueous and ethanolic extracts from Achillea sintenisii Hub-Mor. (AS). To deter-mine the chemical composition of AS extracts, phytochemical analyses were performed by using HPLC-ESI-Q-TOF-MS-MS. Afterwards, both extracts were investigated in terms of their effect on fibroblast proliferation, collagen synthesis, and hydrogen peroxide-induced damage. In addition to cell culture analysis, antibacterial, antioxidant, hyaluronidase inhibitory activities and total phe-nolic contents of the extracts were analyzed in cell-free systems. Our results demonstrated that the aqueous and ethanolic extracts did not show cytotoxic activity on fibroblasts, on the contrary, pro-moted fibroblast proliferation. Both AS extracts potently inhibited hyaluronidase activity and the inhibitory effect of ethanolic extract was comparable with the positive control, especially at high concentrations. The aqueous extract was the potent stimulator of collagen synthesis at 200 mg/mL concentration. Although the ethanolic extract showed antibacterial activity against all gram -positive bacteria, the aqueous extract was only effective against K. pneumoniae and B. subtilis. The ability of AS extracts, which have a rich phenolic compound content (>= 50 mg GAE/g), to scav-enge free radicals and protect fibroblasts against hydrogen peroxide-induced damage can be consid-ered as a result of their antioxidant potential. Our findings scientifically support the widespread use of this plant, by demonstrating the pharmacological properties of the extracts.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.description.sponsorshipDepartment of Scientific Research Projects, Istanbul University-Cerrahpasa, Turkey; [22886]en_US
dc.description.sponsorshipFunding This work was supported by the Department of Scientific Research Projects, Istanbul University-Cerrahpasa, Turkey [Grant No: 22886] .en_US
dc.identifier.doi10.1016/j.arabjc.2022.104426
dc.identifier.issn1878-5352
dc.identifier.issn1878-5379
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85143173395en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.arabjc.2022.104426
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12441
dc.identifier.volume16en_US
dc.identifier.wosWOS:000916163500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇalışkan, Ufuk Koca
dc.institutionauthorDoğan, Üzeyir
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofArabian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAchillea Sintenisii; Fibroblast Proliferation; Antioxidant Activity; Antibacterial Activity; Collagen Synthesis; Hyaluronidase Inhibitory Activityen_US
dc.subjectRadical Scavenging Activity; Antioxidant Activity; Essential Oil; Antimicrobial Activities; Antibacterial Activity; Liquid-Chromatography; Methanol Extracts; Medicinal-Plants; Oxidative Damage; Phenolic Contenten_US
dc.titleIn vitro biological activities and preliminary phytochemical screening of different extracts from Achillea sintenisii Hub- Moren_US
dc.typeArticleen_US

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