High rate of hepatitis B virus DNA positivity in anti-HBc only-positive patients

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dc.contributor.authorYıldırım, Mustafa
dc.contributor.authorYavuz, M. Tevfik
dc.contributor.authorÖzdemir, Davut
dc.contributor.authorBehçet, Mustafa
dc.contributor.authorŞencan, İrfan
dc.date.accessioned2020-05-01T12:10:21Z
dc.date.available2020-05-01T12:10:21Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000258416900022en_US
dc.descriptionPubMed: 18822901en_US
dc.description.abstractIn hepatitis B virus (HBV) infections, detection of only anti-HBc in the absence of HBsAg and anti-HBs is known as 'anti-HBc only' situation. In this study we investigated the rate of HBV-DNA positivity in anti-HBc only-positive 45 patients (29 male, 16 female; mean age: 39.2 +/- 12.3 years) who were followed in the outpatient clinics of a University Hospital in Duzce (located at northern west part of Turkey). HBV markers were investigated by 3rd generation ELISA (MEIA Axsym-Abbott), and HBV-DNA were searched by real-time PCR [extraction: Minielute (Qiagen, Germany); PCR kits: Florion HBV (Iontek, Turkey); detection: i-cycler IQ5 (BioRad, USA)] methods. As a result, 24.4% (11/45) of the patients were found HBV-DNA Positive (> 10(3) copies/ml). There was no statistically significant difference of HBV-DNA positivity rates between males (9/29; 31%) and females (2116; 12.5%), (p = 0.15). It was concluded that there may be a serious risk of HBV transmission from anti-HBc only-positive patients since the rate of HBV-DNA positivity was found high in our study. Thus HBV-DNA screening should be performed in 'anti-HBc only' patient groups.en_US
dc.identifier.endpage536en_US
dc.identifier.issn0374-9096
dc.identifier.issue3en_US
dc.identifier.startpage535en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6158
dc.identifier.volume42en_US
dc.identifier.wosWOS:000258416900022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleHigh rate of hepatitis B virus DNA positivity in anti-HBc only-positive patientsen_US
dc.typeLetteren_US

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